Literature DB >> 14214081

EVIDENCE FOR AN ELECTROPHILIC MECHANISM IN CATALYSIS BY HYDROLYTIC ENZYMES.

H P METZGER, I B WILSON.   

Abstract

Keywords:  ACETYLCHOLINESTERASE; AMMONIUM COMPOUNDS; CARBAMATES; CATALYSIS; CHLORIDES; CHOLINESTERASE INHIBITORS; CHYMOTRYPSIN; ENZYME INHIBITORS; ETHYLAMINES; EXPERIMENTAL LAB STUDY; FLUORIDES; INDOLES; TETRAETHYLAMMONIUM COMPOUNDS; TRYPSIN INHIBITORS

Mesh：

Substances：

Year:  1964        PMID： 14214081     DOI： 10.1021/bi00895a013

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


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  5 in total

1.  Photoregulation of biological activity by photocromic reagents. II. Inhibitors of acetylcholinesterase.

Authors:  J Bieth; S M Vratsanos; N Wassermann; B F Erlanger
Journal:  Proc Natl Acad Sci U S A       Date:  1969-11       Impact factor: 11.205

2.  Photoregulation of biological activity by photochromic reagents, IV. A model for diurnal variation of enzymic activity.

Authors:  J Bieth; N Wassermann; S M Vratsanos; B F Erlanger
Journal:  Proc Natl Acad Sci U S A       Date:  1970-07       Impact factor: 11.205

3.  Probing the topography of the active site of alpha-chymotrypsin.

Authors:  B F Erlanger
Journal:  Proc Natl Acad Sci U S A       Date:  1967-08       Impact factor: 11.205

4.  Phenothiazine-N-carbonyl chloride, a specific inactivator of chymotrypsin.

Authors:  B F Erlanger; S M Vratsanos; N H Wassermann; A G Cooper
Journal:  Biochem J       Date:  1970-07       Impact factor: 3.857

5.  Acetylcholinesterase: evidence that sodium ion binding at the anionic site causes inhibition of the second-order hydrolysis of acetylcholine and a decrease of its pKa as well as of deacetylation.

Authors:  H R Smissaert
Journal:  Biochem J       Date:  1981-07-01       Impact factor: 3.857
  5 in total

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