| Literature DB >> 1421280 |
N I Misuno, T S Kolesnikova, R I Lerer, T Gants, N N Voĭtenok.
Abstract
The influence of human defensin HNP-1 on the synthesis of tumor necrosis factor-alpha (TNF-alpha) by human blood monocytes was studied. It was shown that TNF-alpha production by human monocytes activated by SAC or PMA was augmented in the presence of HNP-1 concentrations of 10(-8)-10(-9) M. HNP-1 alone induced no synthesis of TNF-alpha. High concentration of HNP-1 (10(-4) M) was cytotoxic for human monocytes.Entities:
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Year: 1992 PMID： 1421280
Source DB: PubMed Journal: Biull Eksp Biol Med ISSN： 0365-9615