THE EFFECTS OF SYNTHETIC ELEDOISIN ON THE SYSTEMIC AND CORONARY HAEMODYNAMICS AND METABOLISM OF THE INTACT DOG.

Cardiac output and coronary blood flow were measured before and after intravenous injection of eledoisin into anaesthetized dogs. The following changes, statistically significant at the 5% level, were found: increase of heart rate, and decreases in systemic and pulmonary arterial blood pressure, cardiac output, stroke volume, and in right and left ventricular work. Coronary flow decreased, cardiac oxygen extraction increased, and cardiac efficiency decreased. Many of these effects are similar to those caused by bacterial endotoxin.