Literature DB >> 14211679

HISTAMINE PROTECTION PRODUCED BY PLANT TUMOUR EXTRACTS. THE ACTIVE PRINCIPLE OF TOMATO PLANTS INFECTED WITH GROWN-GALL.

D H CALAM, R K CALLOW.   

Abstract

Guinea-pigs were protected against the lethal effects of a histamine aerosol by intraperitoneal injection of stable extracts of normal tomato plants and of tomato plants infected with crown-gall tumours. The protection was short-lasting. No difference was observed between the activities of extracts of normal and of infected plants. The active principle of the extracts was isolated, and identified as the steroid alkaloid glycoside, tomatine.

Entities:  

Keywords:  ALKALOIDS; EXPERIMENTAL LAB STUDY; GLYCOSIDES; GUINEA PIGS; HISTAMINE; PHARMACOLOGY; PLANT TUMORS; TOMATINE; TOXICOLOGIC REPORT

Mesh：

Substances：

Year:  1964        PMID： 14211679      PMCID： PMC1703940          DOI： 10.1111/j.1476-5381.1964.tb01703.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  10 in total

1.  Biological activity in steroids possessing nitrogen atoms. II. Steroidal alkaloids.

Authors:  M ALAUDDIN; M MARTIN-SMITH
Journal:  J Pharm Pharmacol       Date:  1962-08       Impact factor: 3.765

2.  Some pharmacologic and toxicologic properties of tomatine and its derivatives.

Authors:  R H WILSON; G W POLEY; F DE EDS
Journal:  Toxicol Appl Pharmacol       Date:  1961-01       Impact factor: 4.219

3.  The metabolism of acetyl digitoxin in the rat.

Authors:  J F MARTIN; S E WRIGHT
Journal:  J Pharmacol Exp Ther       Date:  1960-04       Impact factor: 4.030

4.  [Cholesterol tomatide; a new molecular formation for the analysis and preparative extraction of steroids].

Authors:  G SCHULZ; H SANDER
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1957

5.  The metabolites of cardiac glycosides in human urine.

Authors:  J J ASHLEY; B T BROWN; G T OKITA; S E WRIGHT
Journal:  J Biol Chem       Date:  1958-05       Impact factor: 5.157

6.  Bronchoconstrictor agents and their antagonists in the intact guinea-pig.

Authors:  H HERXHEIMER
Journal:  Arch Int Pharmacodyn Ther       Date:  1956-06-01

7.  [Antihistaminic effects of plant tumors].

Authors:  J KOVACS; A KOVACS; L SZABADI; D VARSANYI
Journal:  Arch Int Pharmacodyn Ther       Date:  1952

8.  [A new antihistamine of plant origin].

Authors:  A KOVACS; L SZABADI
Journal:  Arch Int Pharmacodyn Ther       Date:  1950-12

9.  Protection by flavonoids against histamine shock.

Authors:  R H WILSON; A N BOOTH; F DeEDS
Journal:  Proc Soc Exp Biol Med       Date:  1951-03

10.  Histamine protection in guinea-pigs produced by plant tumour extracts.

Authors:  J BROOME; R K CALLOW; W FELDBERG; B A KOVACS
Journal:  Br J Pharmacol Chemother       Date:  1962-02
  10 in total
  2 in total

1.  Histamine protection produced by oak gall extracts.

Authors:  D H Calam
Journal:  Br J Pharmacol Chemother       Date:  1966-03

2.  Anti-inflammatory activity of the steroid alkaloid glycoside, toatine.

Authors:  R B Filderman; B A Kovacs
Journal:  Br J Pharmacol       Date:  1969-11       Impact factor: 8.739
  2 in total

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