Literature DB >> 14209918

ON THE USE OF TRITIUM-LABELLED ALBUMIN FOR STUDIES OF INTESTINAL ABSORPTION.

K N JEEJEEBHOY, J H STEWART, E A EVANS, C C BOOTH.   

Abstract

Human serum albumin has been successfully labelled with tritium. It is considerably denatured in the process and has a shorter half life when given intravenously than (131)I-labelled albumin. Nevertheless it is satisfactory for absorption studies, although not for turnover observations. These studies on absorption in control subjects and in patients with intestinal malabsorption indicate that the excreted radioactivity may have been derived from endogenous sources rather than from the results of malabsorption alone.

Entities:  

Keywords:  BLOOD PROTEIN ELECTROPHORESIS; CHROMATOGRAPHY; CLINICAL RESEARCH; DIOXINS; ENGLAND; ENTERITIS, REGIONAL; FECES; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALABSORPTION SYNDROMES; NITROGEN; PANCREATITIS; POSTGASTRECTOMY SYNDROMES; SERUM ALBUMIN; SODIUM CHLORIDE; SPRUE; STATISTICS; SURGERY, OPERATIVE; TRITIUM

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Substances:

Year:  1964        PMID: 14209918      PMCID: PMC1413463          DOI: 10.1136/gut.5.4.346

Source DB:  PubMed          Journal:  Gut        ISSN: 0017-5749            Impact factor:   23.059


  6 in total

1.  The assay of tritium in biological material by wet oxidation with perchloric acid followed by liquid scintillation counting.

Authors:  E H BELCHER
Journal:  Phys Med Biol       Date:  1960-07       Impact factor: 3.609

2.  The rates and sites of absorption of 131 I-labelled albumin and sodium 131 I in the rat.

Authors:  R A PARKINS; A DIMITRIADOU; C C BOOTH
Journal:  Clin Sci       Date:  1960-11       Impact factor: 6.124

3.  Absorption and elimination of 15-N after administration of isotopically labelled yeast protein and yeast protein hydrolysate to adult patients with coeliac disease. 1. Rate of absorption of 15-N yeast protein and yeast protein hydrolysate.

Authors:  C W CRANE; A NEUBERGER
Journal:  Br Med J       Date:  1960-09-17

4.  Studies of intestinal digestion and absorption in the human.

Authors:  B BORGSTROM; A DAHLQVIST; G LUNDH; J SJOVALL
Journal:  J Clin Invest       Date:  1957-10       Impact factor: 14.808

5.  Use of I131 - labeled protein in the study of protein digestion and absorption in children with and without cystic fibrosis of the pancreas.

Authors:  P S LAVIK; L W MATTHEWS; G W BUCKALOO; F J LEMM; S SPECTOR; H L FRIEDELL
Journal:  Pediatrics       Date:  1952-12       Impact factor: 7.124

6.  Use of I131-labeled protein in the diagnosis of pancreatic insufficiency.

Authors:  A B CHINN; P S LAVIK; R M STITT; G W BUCKALOO
Journal:  N Engl J Med       Date:  1952-12-04       Impact factor: 91.245

  6 in total

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