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Literature DB >> 14209911

STUDIES ON THE MECHANISM OF DESTRUCTION OF THE TOXIC ACTION OF WHEAT GLUTEN IN COELIAC DISEASE BY CRUDE PAPAIN.

Abstract

The toxic action of wheat gluten on two patients was eliminated after predigestion of gluten by crude papain. This change is thought to be due to an enzyme which liberates ammonia from gluten. It is not thought that this particular mechanism operates in the normal intestinal cell but it is envisaged that one of the peptide bonds of the coeliac active constituent (possibly a N-glutaminyl peptide) is normally split by a specific intestinal peptidase which is defective in coeliac patients.

Entities: Chemical Disease Species

Keywords: AMINO ACIDS; AMMONIA; BODY WEIGHT; CELIAC DISEASE; CHILD; DIGESTION; FECES; GLUTEN; INFANT; PAPAIN; PEPTIDE HYDROLASES; PEPTIDES; PYRROLIDINONES; TOXICOLOGIC REPORT; WHEAT

Mesh：

Substances：

Year: 1964 PMID： 14209911 PMCID： PMC1413471 DOI： 10.1136/gut.5.4.295

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

17 in total

1. [Further investigations on the toxic effect of wheat flour in celiac disease. 2. Effect of enzymatic by-products of gliadin].

Authors: H G KRAINICK; G MOHN
Journal: Helv Paediatr Acta Date: 1959-06

STUDIES ON THE MECHANISM OF DESTRUCTION OF THE TOXIC ACTION OF WHEAT GLUTEN IN COELIAC DISEASE BY CRUDE PAPAIN.

1. [Further investigations on the toxic effect of wheat flour in celiac disease. 2. Effect of enzymatic by-products of gliadin].

2. Enzymatic cyclization of L-glutamine and L-glutaminyl peptides.

3. Chymopapain. I. Isolation, crystallization, and preliminary characterization.

4. Pancreatic carboxypeptidases A and B in coeliac disease.

5. Gluten-induced enteropathy: the effect of partially digested gluten.

6. Wheat gluten and coeliac disease.

7. A colorimetric micromethod for determination of ammonia; the ammonia content of rat tissues and human plasma.

8. On the growth defect in coelic disease.

9. Coeliac disease. V. Some experiments on the cause of the harmful effect of wheat gliadin.

10. Enzymic proteolysis: Liberation of ammonia from proteins.

1. Coeliac disease: A review of the causative agents and their possible mechanisms of action.

2. Intestinal peptide transport and hydrolysis in health and disease.

3. Circulating antibodies to wheat gliadin fractions in coeliac disease.

4. A case of adult coeliac disease resistant to treatment.

5. Celiac disease--an inborn error of metabolism.

Review 6. Intestinal malabsorption in childhood.

Review 7. Microbial Proteases in Baked Goods: Modification of Gluten and Effects on Immunogenicity and Product Quality.

8. Digestibility of wheat alpha-amylase/trypsin inhibitors using a caricain digestive supplement.