Literature DB >> 14207455

THALIDOMIDE SYNDROME IN MONKEYS.

C S DELAHUNT, L J LASSEN.   

Abstract

Pregnant monkeys were treated with thalidomide after implantation but before formation of the fetal limbs. Two fetuses that were recovered from the treated females had congenital abnormalities. The thalidomide syndrome in the monkeys was manifested by amelia, phocomelia, internal hydrocephaly, facial capillary hemangioma, hypogenesis of the metatarsal bones, and anotia.

Entities:  

Keywords:  ABNORMALITIES, DRUG-INDUCED; EXPERIMENTAL LAB STUDY; MONKEYS; PREGNANCY; PREGNANCY, ANIMAL; THALIDOMIDE; TOXICOLOGIC REPORT

Mesh：

Substances：

Year:  1964        PMID： 14207455     DOI： 10.1126/science.146.3649.1300

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

1.  Principles of Teratogenesis: Mode of Action of Thalidomide.

Authors:  D H Woollam
Journal:  Proc R Soc Med       Date:  1965-07

Review 2.  Prenatal antidepressant exposure: clinical and preclinical findings.

Authors:  Chase H Bourke; Zachary N Stowe; Michael J Owens
Journal:  Pharmacol Rev       Date:  2014-02-24       Impact factor: 25.468

3.  Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. II. Elucidation of the susceptible period and of the variability of embryonic stages.

Authors:  D Neubert; W Heger; H J Merker; K Sames; R Meister
Journal:  Arch Toxicol       Date:  1988-01       Impact factor: 5.153

4.  [Clinical aspects on chemically produced malformations in animals].

Authors:  L Schreiner; T von Kreybig
Journal:  Arch Klin Exp Ohren Nasen Kehlkopfheilkd       Date:  1968-05-09

Review 5.  Drugs in pregnancy: effects on the fetus and newborn.

Authors:  R M Hill; L Stern
Journal:  Drugs       Date:  1979-03       Impact factor: 9.546

6.  Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. I. Effects of 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (EM12) on skeletal development.

Authors:  H J Merker; W Heger; K Sames; H Stürje; D Neubert
Journal:  Arch Toxicol       Date:  1988-01       Impact factor: 5.153

Review 7.  Thalidomide-type teratogenicity: structure-activity relationships for congeners.

Authors:  R L Smith; S C Mitchell
Journal:  Toxicol Res (Camb)       Date:  2018-09-26       Impact factor: 3.524

8.  Thalidomide teratogenesis: evidence for a toxic arene oxide metabolite.

Authors:  G B Gordon; S P Spielberg; D A Blake; V Balasubramanian
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

9.  Comparative Genomics Identifies Putative Interspecies Mechanisms Underlying Crbn-Sall4-Linked Thalidomide Embryopathy.

Authors:  Thayne Woycinck Kowalski; Gabriela Barreto Caldas-Garcia; Julia do Amaral Gomes; Lucas Rosa Fraga; Lavínia Schuler-Faccini; Mariana Recamonde-Mendoza; Vanessa Rodrigues Paixão-Côrtes; Fernanda Sales Luiz Vianna
Journal:  Front Genet       Date:  2021-06-23       Impact factor: 4.599

10.  Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells.

Authors:  Kesavan Meganathan; Smita Jagtap; Vilas Wagh; Johannes Winkler; John Antonydas Gaspar; Diana Hildebrand; Maria Trusch; Karola Lehmann; Jürgen Hescheler; Hartmut Schlüter; Agapios Sachinidis
Journal:  PLoS One       Date:  2012-08-28       Impact factor: 3.240
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