| Literature DB >> 14207454 |
Abstract
Bacteria may persist in "protoplast" form in kidneys after treatment of experimental enterococcal pyelonephritis with penicillin. Erythromycin, while ineffective against the bacterial form of infection, was able to kill "protoplasts" in vivo. This finding is consistent with the hypothesis that intact cell wall interferes with the ingress of erythromycin into the cellular area in which it acts.Entities:
Keywords: BACTERIOLOGICAL TECHNICS; ERYTHROMYCIN; EXPERIMENTAL LAB STUDY; PENICILLIN G, PROCAINE; PHARMACOLOGY; PYELONEPHRITIS; RATS; STREPTOCOCCUS FAECALIS
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Year: 1964 PMID： 14207454 DOI： 10.1126/science.146.3649.1299
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728