| Literature DB >> 14206439 |
J L FAHEY, J WUNDERLICH, R MISHELL.
Abstract
Two subclasses of mouse 7S gamma(2)-globulins are identified, and are designated gamma(2a)- and gamma(2b)-globulins. They are distinguished from 7S gamma(1)-globulins, gamma(1A) (beta(2A))-globulins, and gamma(1M)-globulins of mouse serum. Antibody activity was detected among the gamma(2a)-globulins and gamma(2b)-globulins of hyperimmune mouse serum. gamma(2a)- and gamma(2b)-myeloma proteins were identified. The genetically determined isoantigen, Iga-1, was present on gamma(2a)-myeloma proteins, but not on gamma(2b)-myeloma proteins. These findings indicate a complexity among the 7S gamma(2)-globulins which must be taken into account in structural, functional, and genetic studies of immunoglobulins.Entities:
Keywords: ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN; GAMMA GLOBULIN, 7S; IMMUNOELECTROPHORESIS; MICE; MULTIPLE MYELOMA; NEOPLASM PROTEINS; PRECIPITIN TESTS; ULTRACENTRIFUGATION
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Year: 1964 PMID： 14206439 PMCID： PMC2137737 DOI： 10.1084/jem.120.2.243
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307