Literature DB >> 1420620

Effect of glucose on perinatal hypoxic-ischemic brain damage.

R C Vannucci1, D J Mujsce.   

Abstract

Investigations suggest that hyperglycemia superimposed on hypoxia-ischemia or cerebral ischemia accentuates brain damage in adult experimental animals and humans. Such does not appear to be the case in immature animals. The present review discusses fundamental differences in immature and adult brain metabolism which account for the age-specific paradox. Based on currently available data, it is recommended that glucose supplementation not be curtailed during labor and delivery of asphyxiated human infants; on the contrary, glucose therapy might substantially reduce hypoxic-ischemic brain damage.

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Year:  1992        PMID： 1420620     DOI： 10.1159/000243874

Source DB:  PubMed          Journal:  Biol Neonate        ISSN： 0006-3126


  8 in total

1.  Early antioxidant treatment and delayed hypothermia after hypoxia-ischemia have no additive neuroprotection in newborn pigs.

Authors:  Xinli Ni; Zeng-Jin Yang; Bing Wang; Erin L Carter; Abby C Larson; Lee J Martin; Raymond C Koehler
Journal:  Anesth Analg       Date:  2012-06-28       Impact factor: 5.108

2.  Management of the asphyxiated full term infant.

Authors:  M I Levene
Journal:  Arch Dis Child       Date:  1993-05       Impact factor: 3.791

3.  Antenatal dexamethasone before asphyxia promotes cystic neural injury in preterm fetal sheep by inducing hyperglycemia.

Authors:  Christopher A Lear; Joanne O Davidson; Georgia R Mackay; Paul P Drury; Robert Galinsky; Josine S Quaedackers; Alistair J Gunn; Laura Bennet
Journal:  J Cereb Blood Flow Metab       Date:  2017-04-07       Impact factor: 6.200

Review 4.  Perioperative central nervous system injury in neonates.

Authors:  M E McCann; S G Soriano
Journal:  Br J Anaesth       Date:  2012-12       Impact factor: 9.166

5.  Hyperglycaemia after Stage I palliation does not adversely affect neurodevelopmental outcome at 1 year of age in patients with single-ventricle physiology.

Authors:  Jean A Ballweg; Richard F Ittenbach; Judy Bernbaum; Marsha Gerdes; Troy E Dominguez; Elaine H Zackai; Robert R Clancy; James William Gaynor
Journal:  Eur J Cardiothorac Surg       Date:  2009-08-20       Impact factor: 4.191

6.  Radioiodinated tracers for the evaluation of dopamine receptors in the neonatal rat brain after hypoxic-ischemic injury.

Authors:  A Zouakia; S Chalon; H F Kung; A M Dognon; E Saliba; J C Besnard; D Guilloteau
Journal:  Eur J Nucl Med       Date:  1994-06

Review 7.  The fetus at the tipping point: modifying the outcome of fetal asphyxia.

Authors:  Simerdeep K Dhillon; Christopher A Lear; Robert Galinsky; Guido Wassink; Joanne O Davidson; Sandra Juul; Nicola J Robertson; Alistair J Gunn; Laura Bennet
Journal:  J Physiol       Date:  2018-06-21       Impact factor: 5.182

Review 8.  Glucocorticoids and preterm hypoxic-ischemic brain injury: the good and the bad.

Authors:  Laura Bennet; Joanne O Davidson; Miriam Koome; Alistair Jan Gunn
Journal:  J Pregnancy       Date:  2012-08-16
  8 in total

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