| Literature DB >> 1420475 |
N H Anderson1, D Johnston, P R Vojvodic.
Abstract
The attempted chromatographic resolution of the drug ciprofibrate and a range of related compounds, containing the chiral moiety 2,2-dichlorocyclopropylbenzene, using five different chiral stationary phases is described. Aqueous mobile phases were used throughout and the successful separation of nine out of 12 pairs of enantiomers was achieved. Structures remote from the chiral centre were seen to affect chiral recognition.Entities:
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Year: 1992 PMID： 1420475 DOI： 10.1016/0731-7085(92)80071-t
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935