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Literature DB >> 14194392

A STUDY OF THE DISTRIBUTION OF INCOMPLETE RHESUS ANTIBODIES AMONG THE SERUM IMMUNOGLOBULIN FRACTIONS.

Abstract

Sera containing Rh antibodies were taken from Rh-negative women at intervals during pregnancy and postpartum. A selection of these was fractionated on DEAE cellulose and by density gradient ultracentrifugation. The distribution among the immunoglobulin fractions gamma(SS), gamma(1)A, and gamma(1)M of Rh antibodies in the sera of Rh-negative women during pregnancy was analysed by these fractionation procedures and also by treatment with 2-mercaptoethanol and by testing with rabbit antisera prepared against purified immunoglobulin fractions. The experiments showed that incomplete Rh antibodies occurred in the 7(SS)-, gamma(1)A-, and gamma(1)M-globulin fractions, although the bulk of the antibody was in the 7(SS). In addition, evidence that the previously described (13) "papain-type" antibody is an incomplete gamma(1)M-globulin is presented.

Entities: Chemical Species

Keywords: CHEMISTRY, ANALYTICAL; CHROMATOGRAPHY; MERCAPTOETHANOL; PHARMACOLOGY; RH FACTORS; SERUM GLOBULINS; SULFHYDRYL COMPOUNDS; ULTRACENTRIFUGATION

Mesh：

Substances：

Year: 1964 PMID： 14194392 PMCID： PMC2137719 DOI： 10.1084/jem.120.1.45

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

11 in total

1. Classification of blood-group antibodies as beta2M or gamma globulin.

Authors: M ADINOLFI; M J POLLEY; D A HUNTER; P L MOLLISON
Journal: Immunology Date: 1962-09 Impact factor: 7.397

2. Rh antibodies detectable only by enzyme technique.

Authors: B E DODD; D A EELES
Journal: Immunology Date: 1961-10 Impact factor: 7.397

3. Chromatographic studies of anomalous gamma-, beta2a-, and macroblobulins and normal gamma-globulins in myeloma and macroglobulinemic sera.

Authors: J L FAHEY
Journal: J Biol Chem Date: 1962-02 Impact factor: 5.157

4. Studies of blood group antibodies. II. Fractionation of Rh antibodies by anion-cation cellulose exchange chromatography.

Authors: N M ABELSON; A J RAWSON
Journal: J Immunol Date: 1959-07 Impact factor: 5.422

5. Human gamma globulin fractionation on anion exchange cellulose columns.

Authors: J L FAHEY; A P HORBETT
Journal: J Biol Chem Date: 1959-10 Impact factor: 5.157

6. Immunochemical studies of human serum Rh agglutinins.

Authors: P C CHAN; H F DEUTSCH
Journal: J Immunol Date: 1960-07 Impact factor: 5.422

7. Separation of complete and incomplete Rh antibodies by centrifugation.

Authors: D H CAMPBELL; P STURGEON; J R VINOGRAD
Journal: Science Date: 1955-12-02 Impact factor: 47.728

8. Chromatography of serum proteins in normal and pathologic sera: the distribution of protein-bound carbohydrate and cholesterol, siderophilin, thyroxin-binding protein, B12-binding protein, alkaline and acid phosphatases, radio-iodinated albumin and myeloma proteins.

Authors: J L FAHEY; P F McCOY; M GOULIAN
Journal: J Clin Invest Date: 1958-02 Impact factor: 14.808

3. Autoimmune hemolytic anemias. I. Investigations on immunoglobulin type and complement fixation of cell-fixed and eluable autoantibodies.

Authors: C Mueller-Eckhardt; V Kretschmer
Journal: Blut Date: 1972-08

A STUDY OF THE DISTRIBUTION OF INCOMPLETE RHESUS ANTIBODIES AMONG THE SERUM IMMUNOGLOBULIN FRACTIONS.

1. Classification of blood-group antibodies as beta2M or gamma globulin.

2. Rh antibodies detectable only by enzyme technique.

3. Chromatographic studies of anomalous gamma-, beta2a-, and macroblobulins and normal gamma-globulins in myeloma and macroglobulinemic sera.

4. Studies of blood group antibodies. II. Fractionation of Rh antibodies by anion-cation cellulose exchange chromatography.

5. Human gamma globulin fractionation on anion exchange cellulose columns.

6. Immunochemical studies of human serum Rh agglutinins.

7. Separation of complete and incomplete Rh antibodies by centrifugation.

8. Chromatography of serum proteins in normal and pathologic sera: the distribution of protein-bound carbohydrate and cholesterol, siderophilin, thyroxin-binding protein, B12-binding protein, alkaline and acid phosphatases, radio-iodinated albumin and myeloma proteins.

9. Studies of antibody distribution in the serum proteins of several Rh antisera.

10. The association of skin-sensitizing antibody with the beta 2A-globulins in sera from ragweed-sensitive patients.

1. Compleat immunology: science or septophrenia?

2. Inhibition of the anti-globulin reaction by human immunoglobulin G and its fragments.

3. Autoimmune hemolytic anemias. I. Investigations on immunoglobulin type and complement fixation of cell-fixed and eluable autoantibodies.

4. Anti-K2(Cellano) blood group antibodies. Typing as IgG and IgA with a review of their clinical significance.

5. A Low Molecular Weight Immunoglobulin Antigenically Related to 19 S IgM.

6. Gamma-A-blood group antibodies.