Literature DB >> 14194103

HEMOGLOBINS A AND F: FORMATION IN THALASSEMIA AND OTHER HEMOLYTIC ANEMIAS.

P A MARKS, E R BURKA.   

Abstract

Rates of synthesis of hemoglobin A by erythroid cells from thalassemic subjects are markedly decreased. Formation of hemoglobin F, however, proceeds at similar rates in cells from subjects with thalassemia and other types of hemolytic anemias. A mechanism is suggested regarding the altered patterns of hemoglobin synthesis under conditions of erythropoietic stimulation in subjects with and without thalassemia.

Entities:  

Keywords:  CARBON ISOTOPES; DNA; ERYTHROPOIESIS; HEMOGLOBINS, ABNORMAL; HISTOCYTOCHEMISTRY; ISOLEUCINE; LEUCINE; PROTEIN METABOLISM; RIBOSOMES; RNA; THALASSEMIA

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Year:  1964        PMID： 14194103     DOI： 10.1126/science.144.3618.552

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  STUDIES ON HEMOGLOBIN BIOSYNTHESIS: ASYNCHRONOUS SYNTHESIS OF HEMOGLOBIN A AND HEMOGLOBIN A2 BY ERYTHROCYTE PRECURSORS.

Authors:  R F RIEDER; D J WEATHERALL
Journal:  J Clin Invest       Date:  1965-01       Impact factor: 14.808

2.  THE DISTRIBUTION OF HEMOGLOBIN TYPES IN THALASSEMIC ERYTHROCYTES.

Authors:  D LOUKOPOULOS; P FESSAS
Journal:  J Clin Invest       Date:  1965-02       Impact factor: 14.808

3.  Thalassaemia.

Authors:  E R Huehns
Journal:  Postgrad Med J       Date:  1965-12       Impact factor: 2.401

4.  Hemoglobin F synthesis in vitro: evidence for control at the level of primitive erythroid stem cells.

Authors:  T Papayannopoulou; M Brice; G Stamatoyannopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

5.  Cellular regulation of hemoglobin switching: evidence for inverse relationship between fetal hemoglobin synthesis and degree of maturity of human erythroid cells.

Authors:  T Papayannopoulou; T Kalmantis; G Stamatoyannopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

6.  Irreversibly sickled erythrocytes: a consequence of the heterogeneous distribution of hemoglobin types in sickle-cell anemia.

Authors:  J F Bertles; P F Milner
Journal:  J Clin Invest       Date:  1968-08       Impact factor: 14.808

7.  Problems of reduced heme synthesis in reticulocytes with impaired globin synthesis.

Authors:  J Neuwirt; P Ponka; J Borová; J F Prchal
Journal:  Blut       Date:  1969-04

8.  Protein synthesis in a cell free human reticulocyte system: ribosome function in thalassemia.

Authors:  A Bank; P A Marks
Journal:  J Clin Invest       Date:  1966-03       Impact factor: 14.808

9.  Disproportional synthesis of the adult duck's two hemoglobins during acute anemia.

Authors:  J F Bertles; T A Borgese
Journal:  J Clin Invest       Date:  1968-03       Impact factor: 14.808
  9 in total

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