| Literature DB >> 14194099 |
J C ROGER, H CHAMBERS, J E CASIDA.
Abstract
Embryonic abnormalities are known to be induced in chick embryos when they are injected with certain organophosphate insecticides prior to incubation. The marked teratogenic effects of Bidrin [3-(dimethoxyphosphinyloxy) N, N-dimethyl-cis-crotonamide] can be alleviated by many analogs of nicotinamide and nicotinamide adenine dinucleotide. Successive hydroxylation and N-dealkylation of Bidrin in the egg are not greatly altered by injection of nicotinamide. The delayed neurotoxicity in adult hens after administering tri-o-cresyl phosphate is also partially relieved by administering certain nicotinamide analogs.Entities:
Keywords: ABNORMALITIES, DRUG-INDUCED; BIOLOGICAL ASSAY; CARBAMATES; CENTRAL NERVOUS SYSTEM; CHICK EMBRYO; CHOLINESTERASE; CRESOLS; EXPERIMENTAL LAB STUDY; GLOSSITIS; GROWTH; HISTOCYTOCHEMISTRY; NAD; NICOTINAMIDE; PHARMACOLOGY; PHOSPHATES; POULTRY; TOXICOLOGIC REPORT
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Year: 1964 PMID： 14194099 DOI： 10.1126/science.144.3618.539
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728