| Literature DB >> 14190474 |
Abstract
The Robbins-Monro process is a sequential procedure which can be used in toxicity assays. The principal advantages are maximal economy of drug and animals and immediate availability of an estimate of the LD50 at any stage in the assay. The disadvantages are the need to wait for the outcome in each group of animals before testing the next group and the lack of an accurate method for determining confidence limits. Some practical details of the application of the method are given.Entities:
Keywords: BIOLOGICAL ASSAY; EXPERIMENTAL LAB STUDY; MICE; TOXICOLOGIC REPORT; VERATRUM
Mesh：
Year: 1964 PMID： 14190474 PMCID： PMC1703981 DOI： 10.1111/j.1476-5381.1964.tb02044.x
Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826