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Literature DB >> 14190472

POTENTIATION OF THE ACTION OF BRADYKININ ON SMOOTH MUSCLE BY CHYMOTRYPSIN, CHYMOTRYPSINOGEN AND TRYPSIN.

Abstract

Chymotrypsin, chymotrypsinogen and trypsin sensitized the guinea-pig isolated ileum and rat isolated uterus preparations to the action of bradykinin, whilst the responses to histamine, acetylcholine and 5-hydroxytryptamine were unaffected. Chymotrypsin caused a quick contraction of the guinea-pig ileum which was abolished by mepyramine and therefore probably mediated by histamine. Trypsin contracted the rat uterus as well as the guinea-pig ileum; the latter contraction was slow, resistant to mepyramine and gave rise to tachyphylaxis. It is suggested that isolated smooth muscle preparations should be treated with chymotrypsin for use in the estimation of minute amounts of bradykinin.

Entities: Chemical Disease Species

Keywords: ACETYLCHOLINE; ANTIHISTAMINICS; BRADYKININ; CHYMOTRYPSIN; ENZYME PRECURSORS; EXPERIMENTAL LAB STUDY; GUINEA PIGS; HISTAMINE; ILEUM; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PHARMACOLOGY; RATS; SEROTONIN; TACHYPHYLAXIS; TRYPSIN; UTERUS

Mesh：

Substances：

Year: 1964 PMID： 14190472 PMCID： PMC1703969 DOI： 10.1111/j.1476-5381.1964.tb02042.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

11 in total

2. The action of trypsin on blockade by 2-halogenoalkylamines: speculation on the nature of the alpha receptor for catecholamine.

Authors: J D Graham; H Al Katib
Journal: Br J Pharmacol Chemother Date: 1966-10

6. Release of prostaglandins mediating the potentiation of bradykinin by BPF and chymotrypsin in rate isolated ileum [proceedings].

Authors: H Edery; M Shemesh
Journal: Agents Actions Date: 1978-01

10. Receptors for bradykinin in intact cultured human fibroblasts. Identification and characterization by direct binding study.

Authors: A A Roscher; V C Manganiello; C L Jelsema; J Moss
Journal: J Clin Invest Date: 1983-08 Impact factor: 14.808

10 in total

POTENTIATION OF THE ACTION OF BRADYKININ ON SMOOTH MUSCLE BY CHYMOTRYPSIN, CHYMOTRYPSINOGEN AND TRYPSIN.

1. ANTAGONISTIS OF BRADYKININ.

2. Classification of intestinomotor drugs by means of type D botulinum toxin.

3. A slow contracting substance in normal human urine.

4. Nonspecific catalyses by alpha-chymotrypsin and trypsin.

5. Active polypeptides derived from plasma proteins.

6. Formation of plasma kinins by plasmin.

7. The effects of proteolytic enzymes on the isolated rabbit intestine.

8. Bradykinin.

9. Effects of ganglion-blocking substances on the small intestine.

10. The biological estimation of 5-hydroxytryptamine (enteramine) in the presence of substance P.

1. FURTHER STUDIES OF THE SENSITIZATION OF SMOOTH MUSCLE TO THE ACTION OF PLASMA KININS BY PROTEOLYTIC ENZYMES.

2. The action of trypsin on blockade by 2-halogenoalkylamines: speculation on the nature of the alpha receptor for catecholamine.

3. The kinin-forming and kininase activities of rabbit polymorphonuclear leucocytes.

4. Sensitization of guinea-pig ileum to the action of bradykinin by trypsin hydrolysate of ox and rabbit plasma.

5. The pharmacology of slow reacting substance C and of arachidonic acid. 1973.

6. Release of prostaglandins mediating the potentiation of bradykinin by BPF and chymotrypsin in rate isolated ileum [proceedings].

Review 7. The pharmacology of slow reacting substance C and of arachidonic acid.

8. Mechanism of action of chymotrypsin on plain muscle.

9. Liberation of a bradykinin-like substance in the circulating blood of dogs by trypsin, chymotrypsin and nagarse.

10. Receptors for bradykinin in intact cultured human fibroblasts. Identification and characterization by direct binding study.