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Literature DB >> 14190468

THE EFFECTS OF ANTIMONY UPTAKE ON THE LOCATION AND PAIRING OF SCHISTOSOMA MANSONI.

Abstract

The rate of uptake and elimination of antimony by both male and female schistosomes has been measured. It has been confirmed that the female schistosome is more susceptible to antimony therapy than the male since she absorbs more drug. The changes in location of the worms and the separation of the sexes following one or more injections of antimony potassium tartrate have been related to the different rates of uptake and elimination of the drug by the two sexes. The suppressive treatment of schistosomiasis is discussed in the light of these observations.

Entities: Chemical Disease Species

Keywords: ANTHELMINTICS; ANTIMONY; EXPERIMENTAL LAB STUDY; METABOLISM; MICE; PHARMACOLOGY; SCHISTOSOMA; SCHISTOSOMIASIS

Mesh：

Substances：

Year: 1964 PMID： 14190468 PMCID： PMC1703985 DOI： 10.1111/j.1476-5381.1964.tb02038.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

5 in total

1. Rapid hepatic shift of worms in mice infected with Schistosoma mansoni after a single injection of tartar emetic.

Authors: G A BUTTLE; M T KHAYYAL
Journal: Nature Date: 1962-05-26 Impact factor: 49.962

2. Anthelmintics.

Authors: E BUEDING; C SWARTZWELDER
Journal: Pharmacol Rev Date: 1957-09 Impact factor: 25.468

3. Experimental schistosomiasis. III. Chemotherapy and mode of drug action.

Authors: O D STANDEN
Journal: Ann Trop Med Parasitol Date: 1953-03

4. Experimental schistosomiasis; maintenance of Schistosoma mansoni in the laboratory, with some notes on experimental infection with S. haematobium.

Authors: O D STANDEN
Journal: Ann Trop Med Parasitol Date: 1949-12

5. Treatment of schistosomiasis, past & present. II. Clinical investigations on the treatment of urinary and intestinal bilharziasis with TWSb (antimonv dimercaptosuccinate) with a critical study of its toxic side effects.

Authors: H F NAGATY; M A RIFAAT
Journal: J Egypt Med Assoc Date: 1960

5 in total

6 in total

6. The uptake of tritiated hycanthone by male and female Schistosoma mansoni worms and distribution of the drug in plasma and whole blood of mice following a single intramuscular injection.

Authors: A Yarinsky; P Hernandez; E W Dennis
Journal: Bull World Health Organ Date: 1970 Impact factor: 9.408

6 in total

THE EFFECTS OF ANTIMONY UPTAKE ON THE LOCATION AND PAIRING OF SCHISTOSOMA MANSONI.

1. Rapid hepatic shift of worms in mice infected with Schistosoma mansoni after a single injection of tartar emetic.

2. Anthelmintics.

3. Experimental schistosomiasis. III. Chemotherapy and mode of drug action.

4. Experimental schistosomiasis; maintenance of Schistosoma mansoni in the laboratory, with some notes on experimental infection with S. haematobium.

5. Treatment of schistosomiasis, past & present. II. Clinical investigations on the treatment of urinary and intestinal bilharziasis with TWSb (antimonv dimercaptosuccinate) with a critical study of its toxic side effects.

1. The use of penicillamine as an adjuvant to tartar emetic in the treatment of experimental schistosomiasis.

2. Tissue distribution of trivalent antimony in mice infected with Schistosoma mansoni.

3. Comparison of the chemotherapeutic potencies of 4 antimonial drugs.

4. Treatment of intestinal bilharziasis with antimonials: the possible use of dimercaprol as an adjuvant to therapy.

5. Observations on "lung shift" after chemotherapy in mice infected with Schistosoma mansoni.

6. The uptake of tritiated hycanthone by male and female Schistosoma mansoni worms and distribution of the drug in plasma and whole blood of mice following a single intramuscular injection.