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Literature DB >> 14190243

AMINO ACIDS: INCORPORATION INTO ALPHA- AND BETA-CHAINS OF HEMOGLOBIN BY NORMAL AND THALASSEMIC RETICULOCYTES.

Abstract

After incubation of reticulocytes with radioactive amino acid, the specific activity of the beta-chain of globin from the blood of patients with thalassemia was consistently lower than that of the alpha-chain. In subjects without this disorder, the specific activity of the beta-chain was always equal to or higher than that of the alpha-chain.

Entities: Chemical Disease Gene Species

Keywords: ANEMIA, SICKLE CELL; CARBON ISOTOPES; EXPERIMENTAL LAB STUDY; HEMOGLOBIN; LEUCINE; LEUKEMIA; PROTEIN METABOLISM; RETICULOCYTES; THALASSEMIA; VALINE

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Year: 1964 PMID： 14190243 DOI： 10.1126/science.146.3643.530

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

7 in total

1. Equal synthesis of - and -globin chains in erythroid precursors in heterozygous -thalassemia.

Authors: Y W Kan; D G Nathan; H F Lodish
Journal: J Clin Invest Date: 1972-07 Impact factor: 14.808

2. Rate of synthesis of haemoglobin A2 in thalassaemia.

Authors: F Schettini; G Di Bitonto; A Mautone
Journal: Z Kinderheilkd Date: 1971

3. Hemoglobin messenger RNA from human bone marrow. Isolation and translation in homozygous and heterozygous beta-thalassemia.

Authors: A W Nienhuis; P H Canfield; W F Anderson
Journal: J Clin Invest Date: 1973-07 Impact factor: 14.808

AMINO ACIDS: INCORPORATION INTO ALPHA- AND BETA-CHAINS OF HEMOGLOBIN BY NORMAL AND THALASSEMIC RETICULOCYTES.

1. Equal synthesis of - and -globin chains in erythroid precursors in heterozygous -thalassemia.

2. Rate of synthesis of haemoglobin A2 in thalassaemia.

3. Hemoglobin messenger RNA from human bone marrow. Isolation and translation in homozygous and heterozygous beta-thalassemia.

4. Mild thalassemia: the result of interactions of alpha and beta thalassemia genes.

5. Quantitative deficiency of chain-specific globin messenger ribonucleic acids in the thalassemia syndromes.

6. Defect in messenger RNA for human hemoglobin synthesis in beta thalassemia.

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