Molecular genetics of familial hypercholesterolaemia: common and rare mutations of the low density lipoprotein receptor gene.

Mutations of the low density lipoprotein (LDL) receptor gene give rise to familial hypercholesterolaemia (FH), one of the most common single-gene diseases in the world. Approximately 150 different LDL receptor gene mutations have been reported until now and the list seems to be continuously growing. Although hampering molecular genetic diagnosis of FH, this wide variability at the DNA level provides a useful tool to population genetics and may ultimately lead to better understanding of the variation in disease manifestations from family to family. The Finns are among the few populations in which one or two mutant LDL receptor genes explain the majority of FH cases. Either of the two 'Finnish-type' LDL receptor gene deletions, FH-Helsinki or FH-North Karelia, is present in more than 60% of the Finnish FH patients; there are no reports on their existence in other ethnic groups. Assays for these mutations were shown to markedly complement clinical diagnosis of FH in Finland.