Literature DB >> 1418703

Signal transduction by T- and B-cell antigen receptors: converging structures and concepts.

J C Cambier1.   

Abstract

Recent evidence demonstrates that the antigen receptor complexes of T and B lymphocytes are very similar in general architecture and primary and secondary structure of component polypeptides, and that they use common mechanisms for transmembrane signal transduction. Most importantly, multiple subunits of each receptor (Ig-alpha, Ig-beta and Ig-gamma, CD3 gamma, CD3 delta and CD3 epsilon, and T-cell receptor zeta and eta) possess a motif of approximately 26 amino-acids, denoted ARH1, which appears to carry sufficient structural information for receptor-mediated lymphocyte activation.

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Year:  1992        PMID： 1418703     DOI： 10.1016/0952-7915(92)90074-o

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  15 in total

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8.  CD22 associates with the human surface IgM-B-cell antigen receptor complex.

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9.  Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins.

Authors:  E N Neumeister; Y Zhu; S Richard; C Terhorst; A C Chan; A S Shaw
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10.  Multiple motifs regulate the B-cell-specific promoter of the B29 gene.

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