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Literature DB >> 14185980

QUINAZOLINES AND 1,4-BENZODIAZEPINES. X. NITRO-SUBSTITUTED 5-PHENYL-1,4-BENZODIAZEPINE DERIVATIVES.

L H STERNBACH, R I FRYER, O KELLER, W METLESICS, G SACH, N STEIGER.

Abstract

Entities: Chemical

Keywords: ANTICONVULSANTS; CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; HETEROCYCLIC COMPOUNDS; HYPNOTICS AND SEDATIVES; MICE; MUSCLE RELAXANTS; PHARMACOLOGY; TOXICOLOGIC REPORT

Mesh：

Substances：

Year: 1963 PMID： 14185980 DOI： 10.1021/jm00339a010

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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Cited

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10 in total

1. Detection and identification of nitrazepam and related compounds by thin-layer chromatography.

Authors: H Sawada; K Shinohara
Journal: Arch Toxikol Date: 1970

2. Studies on the absorption, distribution and elimination of 6-o-chlorophenyl-2,4-dihydro-2(N-methyl-piperazin-1-yl)-methylene-8-nitro-1H-imidazo[1,2-a] [1,4]benzodiazepin-1-one methanesulphonate in the male rat and rabbit.

Authors: G W James; P D Kennewell; J B Taylor; D K Luscombe; P J Nicholls
Journal: Eur J Drug Metab Pharmacokinet Date: 1979 Impact factor: 2.441

3. Anticonvulsive Activity in Audiogenic DBA/2 Mice of 1,4-Benzodiazepines and 1,5-Benzodiazepines with Different Activities at Cerebellar Granule Cell GABA_A Receptors.

Authors: Elena Gatta; Aroldo Cupello; Mario Di Braccio; Giancarlo Grossi; Mauro Robello; Francesca Scicchitano; Emilio Russo; Giovambattista De Sarro
Journal: J Mol Neurosci Date: 2016-09-15 Impact factor: 3.444

QUINAZOLINES AND 1,4-BENZODIAZEPINES. X. NITRO-SUBSTITUTED 5-PHENYL-1,4-BENZODIAZEPINE DERIVATIVES.

1. Detection and identification of nitrazepam and related compounds by thin-layer chromatography.

2. Studies on the absorption, distribution and elimination of 6-o-chlorophenyl-2,4-dihydro-2(N-methyl-piperazin-1-yl)-methylene-8-nitro-1H-imidazo[1,2-a] [1,4]benzodiazepin-1-one methanesulphonate in the male rat and rabbit.

3. Anticonvulsive Activity in Audiogenic DBA/2 Mice of 1,4-Benzodiazepines and 1,5-Benzodiazepines with Different Activities at Cerebellar Granule Cell GABA_A Receptors.

Review 4. Molecular mechanisms of antiseizure drug activity at GABAA receptors.

5. Prevention of drug-induced memory impairment by immunopharmacotherapy.

6. Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells.

Review 7. Metabolites replace the parent drug in the drug arena. The cases of fonazepam and nifoxipam.

Review 8. 'New/Designer Benzodiazepines': An Analysis of the Literature and Psychonauts' Trip Reports.

Review 9. Prescribed drugs containing nitrogen heterocycles: an overview.

Review 10. Designer Benzodiazepines: A Review of Toxicology and Public Health Risks.

QUINAZOLINES AND 1,4-BENZODIAZEPINES. X. NITRO-SUBSTITUTED 5-PHENYL-1,4-BENZODIAZEPINE DERIVATIVES.

1. Detection and identification of nitrazepam and related compounds by thin-layer chromatography.

2. Studies on the absorption, distribution and elimination of 6-o-chlorophenyl-2,4-dihydro-2(N-methyl-piperazin-1-yl)-methylene-8-nitro-1H-imidazo[1,2-a] [1,4]benzodiazepin-1-one methanesulphonate in the male rat and rabbit.

3. Anticonvulsive Activity in Audiogenic DBA/2 Mice of 1,4-Benzodiazepines and 1,5-Benzodiazepines with Different Activities at Cerebellar Granule Cell GABAA Receptors.

Review 4. Molecular mechanisms of antiseizure drug activity at GABAA receptors.

5. Prevention of drug-induced memory impairment by immunopharmacotherapy.

6. Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells.

Review 7. Metabolites replace the parent drug in the drug arena. The cases of fonazepam and nifoxipam.

Review 8. 'New/Designer Benzodiazepines': An Analysis of the Literature and Psychonauts' Trip Reports.

Review 9. Prescribed drugs containing nitrogen heterocycles: an overview.

Review 10. Designer Benzodiazepines: A Review of Toxicology and Public Health Risks.

3. Anticonvulsive Activity in Audiogenic DBA/2 Mice of 1,4-Benzodiazepines and 1,5-Benzodiazepines with Different Activities at Cerebellar Granule Cell GABA_A Receptors.