Literature DB >> 1418372

Immunotoxins: the power and the glory.

E J Wawrzynczak1, E J Derbyshire.   

Abstract

Immunotoxins are hybrid proteins in which the potent cytocidal action of a toxin is harnessed for the selective destruction of target cells by attachment to a specific monoclonal antibody (mAb) or growth factor. This brief article describes the latest advances in the molecular and cellular biology, pharmacology and clinical evaluation of immunotoxins, as discussed at a recent meeting.

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Year:  1992        PMID： 1418372     DOI： 10.1016/0167-5699(92)90084-K

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  2 in total

1.  NIM-R7, a novel marker for resting B1 and marginal-zone B lymphocytes, is also expressed on activated T and B cells.

Authors:  Nataly Manjarrez-Orduño; R Michael E Parkhouse; Leopoldo Santos-Argumedo
Journal:  Immunology       Date:  2003-06       Impact factor: 7.397

2.  Refinement of an indirect immunotoxin assay of monoclonal antibodies recognising the human small cell lung cancer cluster 2 antigen.

Authors:  E J Derbyshire; L de Leij; E J Wawrzynczak
Journal:  Br J Cancer       Date:  1993-06       Impact factor: 7.640
  2 in total

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