Literature DB >> 141808

Renal aminoacylase, a zinc enzyme.

W Kördel, F Schneider.   

Abstract

Renal aminoacylase is inactivated by dialysis against metal complexing agents such as o-phenanthroline. Activity can be restored by addition of zinc ions. A zinc dissociation constant of about 10(-10)M at pH 7.8 is obtained by titration of the enzyme with a metal ion buffer. The reactivity of the SH groups of the enzyme is considerably affected by zinc ions. The enzyme contains two essential zinc ions per molecule.

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Year:  1977        PMID： 141808     DOI： 10.1515/znc-1977-5-605

Source DB:  PubMed          Journal:  Z Naturforsch C Biosci        ISSN： 0341-0382


  7 in total

1.  Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.

Authors:  Kirill Tsirulnikov; Natalia Abuladze; Anatol Bragin; Kym Faull; Duilio Cascio; Robert Damoiseaux; Matthew J Schibler; Alexander Pushkin
Journal:  Toxicol Appl Pharmacol       Date:  2012-07-20       Impact factor: 4.219

2.  Inactivation and conformational changes of aminoacyclase in trifluoroethanol solutions.

Authors:  Y X Zhang; S L Yan; H M Zhou
Journal:  J Protein Chem       Date:  1996-10

3.  Kinetics of the course of reactivation of aminoacylase reconstituted using Mn2+ ions.

Authors:  Y X Zhang; W P Le; H M Zhou
Journal:  J Protein Chem       Date:  1995-11

4.  A comparison of Zn(II) and Co(II) in the kinetics of inactivation of aminoacylase by 1,10-phenanthroline and reconstitution of the apoenzyme.

Authors:  H B Wu; C L Tsou
Journal:  Biochem J       Date:  1993-12-01       Impact factor: 3.857

5.  Kinetics of the course of inactivation of aminoacylase by 1,10-phenanthroline.

Authors:  Z X Wang; H B Wu; X C Wang; H M Zhou; C L Tsou
Journal:  Biochem J       Date:  1992-01-01       Impact factor: 3.857

6.  Inactivation and unfolding of aminoacylase during denaturation in sodium dodecyl sulfate solutions.

Authors:  B He; Y Zhang; T Zhang; H R Wang; H M Zhou
Journal:  J Protein Chem       Date:  1995-07

7.  Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel.

Authors:  Kirill Tsirulnikov; Natalia Abuladze; Debra Newman; Sergey Ryazantsev; Talya Wolak; Nathaniel Magilnick; Myong-Chul Koag; Ira Kurtz; Alexander Pushkin
Journal:  Biochim Biophys Acta       Date:  2009-04-09
  7 in total

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