Literature DB >> 1417927

Zidovudine-induced blockade of the expression and function of the erythropoietin receptor.

S R Gogu1, J S Malter, K C Agrawal.   

Abstract

Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 microM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity.

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Year:  1992        PMID： 1417927     DOI： 10.1016/0006-2952(92)90361-l

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  4 in total

1.  Influence of new antiretrovirals on hematological toxicity in HIV-exposed uninfected infants.

Authors:  Núria Rovira; Antoni Noguera-Julian; Susana Rives; Rubén Berrueco; Rebeca Lahoz; Clàudia Fortuny
Journal:  Eur J Pediatr       Date:  2016-05-10       Impact factor: 3.183

2.  Pharmacokinetics and pharmacodynamics of erythropoietin receptor in healthy volunteers.

Authors:  Wojciech Krzyzanski; Elzbieta Wyska
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-12-11       Impact factor: 3.000

Review 3.  Inadequate erythropoietin response to anemia: definition and clinical relevance.

Authors:  G Barosi
Journal:  Ann Hematol       Date:  1994-05       Impact factor: 3.673

4.  Effects of 2',3'-dideoxynucleosides on proliferation and differentiation of human pluripotent progenitors in liquid culture and their effects on mitochondrial DNA synthesis.

Authors:  A Faraj; D A Fowler; E G Bridges; J P Sommadossi
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191
  4 in total

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