Literature DB >> 1417828

Activation of phospholipase C by the agonist U46619 is inhibited by cromakalim-induced hyperpolarization in porcine coronary artery.

T Yamagishi1, T Yanagisawa, N Taira.   

Abstract

We measured inositol 1,4,5-trisphosphate (IP3) production, intracellular calcium concentration ([Ca2+]i) and force of contraction induced by a thromboxane A2 analogue U46619 in porcine coronary artery to elucidate the relaxant effect of a K+ channel opener cromakalim. Cromakalim (10 microM) significantly inhibited the production of IP3, Ca2+ release from intracellular stores and contraction induced by 300 nM U46619. The inhibitory effect of cromakalim on IP3 was blocked by a K+ channel blocker tetrabutylammonium (TBA, 3 mM) and counteracted by 20 mM KCl-induced depolarization. These results suggest that the hyperpolarization of the plasma membrane by cromakalim inhibits the activation of phospholipase via the stimulation of the thromboxane A2 receptor to result in vasodilation.

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Year:  1992        PMID： 1417828     DOI： 10.1016/0006-291x(92)90474-y

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

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Authors:  J Kawahara; H Izumi; Y Okada; T Izawa
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3.  Evidence for mediation by endothelium-derived hyperpolarizing factor of relaxation to bradykinin in the bovine isolated coronary artery independently of voltage-operated Ca2+ channels.

Authors:  G R Drummond; T M Cocks
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4.  The effects of a novel vasodilator, LP-805, on cytosolic Ca2+ concentrations and on tension in rabbit isolated femoral arteries.

Authors:  M Ushio-Fukai; K Hirano; H Kanaide
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5.  Endothelium-derived hyperpolarizing factor but not NO reduces smooth muscle Ca2+ during acetylcholine-induced dilation of microvessels.

Authors:  S S Bolz; C de Wit; U Pohl
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6.  Thromboxane-induced renal vasoconstriction is mediated by the ADP-ribosyl cyclase CD38 and superoxide anion.

Authors:  Nicholas G Moss; Paul A Vogel; Tayler E Kopple; William J Arendshorst
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7.  Hyperpolarization induced by K+ channel openers inhibits Ca2+ influx and Ca2+ release in coronary artery.

Authors:  T Yanagisawa; T Yamagishi; Y Okada
Journal:  Cardiovasc Drugs Ther       Date:  1993-08       Impact factor: 3.727

8.  Inhibition of muscarinic receptor-induced inositol phospholipid hydrolysis by caffeine, beta-adrenoceptors and protein kinase C in intestinal smooth muscle.

Authors:  S A Prestwich; T B Bolton
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9.  BRL 38227 (levcromakalim)-induced hyperpolarization reduces the sensitivity to Ca2+ of contractile elements in canine coronary artery.

Authors:  Y Okada; T Yanagisawa; N Taira
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-04       Impact factor: 3.000
  9 in total

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