Literature DB >> 1417812

N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties.

J M Fukuto1, R Hszieh, P Gulati, K T Chiang, H T Nagasawa.   

Abstract

N,O-Diacylated-N-hydroxyarylsulfonamides are capable of slowly releasing nitroxyl (HNO) by simple, non-enzymatic hydrolysis in Krebs solution at 37 degrees C. Release of nitric oxide (NO) was not seen. These compounds were also found to elicit vasorelaxation in rabbit thoracic aorta in vitro, presumably as a result of their ability to release HNO. This effect was enhanced by the addition of superoxide dismutase (SOD). Thus, these results are consistent with previous work indicating that HNO is a potent vasorelaxant.

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Year:  1992        PMID： 1417812     DOI： 10.1016/0006-291x(92)90453-r

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

Review 1.  The emergence of nitroxyl (HNO) as a pharmacological agent.

Authors:  Christopher H Switzer; Wilmarie Flores-Santana; Daniele Mancardi; Sonia Donzelli; Debashree Basudhar; Lisa A Ridnour; Katrina M Miranda; Jon M Fukuto; Nazareno Paolocci; David A Wink
Journal:  Biochim Biophys Acta       Date:  2009-05-06

2.  Oxidation of nitroxyl anion to nitric oxide by copper ions.

Authors:  S Nelli; M Hillen; K Buyukafsar; W Martin
Journal:  Br J Pharmacol       Date:  2000-09       Impact factor: 8.739

Review 3.  The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.

Authors:  Wilmarie Flores-Santana; Debra J Salmon; Sonia Donzelli; Christopher H Switzer; Debashree Basudhar; Lisa Ridnour; Robert Cheng; Sharon A Glynn; Nazareno Paolocci; Jon M Fukuto; Katrina M Miranda; David A Wink
Journal:  Antioxid Redox Signal       Date:  2011-03-16       Impact factor: 8.401

Review 4.  Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application.

Authors:  Vindhya Koppaka; David C Thompson; Ying Chen; Manuel Ellermann; Kyriacos C Nicolaou; Risto O Juvonen; Dennis Petersen; Richard A Deitrich; Thomas D Hurley; Vasilis Vasiliou
Journal:  Pharmacol Rev       Date:  2012-04-27       Impact factor: 25.468

5.  Reactions of HNO with heme proteins: new routes to HNO-heme complexes and insight into physiological effects.

Authors:  Murugaeson R Kumar; Jon M Fukuto; Katrina M Miranda; Patrick J Farmer
Journal:  Inorg Chem       Date:  2010-07-19       Impact factor: 5.165

6.  Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class.

Authors:  Daniela Andrei; Debra J Salmon; Sonia Donzelli; Azadeh Wahab; John R Klose; Michael L Citro; Joseph E Saavedra; David A Wink; Katrina M Miranda; Larry K Keefer
Journal:  J Am Chem Soc       Date:  2010-10-29       Impact factor: 15.419

Review 7.  The emerging multifaceted roles of nitric oxide.

Authors:  P C Kuo; R A Schroeder
Journal:  Ann Surg       Date:  1995-03       Impact factor: 12.969

8.  Oxidative release of nitric oxide accounts for guanylyl cyclase stimulating, vasodilator and anti-platelet activity of Piloty's acid: a comparison with Angeli's salt.

Authors:  R Zamora; A Grzesiok; H Weber; M Feelisch
Journal:  Biochem J       Date:  1995-12-01       Impact factor: 3.857

9.  Quinone-enhanced reduction of nitric oxide by xanthine/xanthine oxidase.

Authors:  Pedro Sanchez-Cruz; Antonio E Alegría
Journal:  Chem Res Toxicol       Date:  2009-05       Impact factor: 3.739
  9 in total

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