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Literature DB >> 1417810

CDw 60 antibodies bind to acetylated forms of ganglioside GD3.

B Kniep¹, J Peter-Katalinić, W Flegel, H Northoff, E P Rieber.

Abstract

Four monoclonal antibodies, M-T21, M-T32, M-T41 and UM4D4, which belong to the new CDw 60 cluster of antibodies specific for a subpopulation of human T-lymphocytes, were found to bind mainly to acetylated forms of ganglioside GD3. After O-deacetylation of the antigen, binding was reduced ("M-T"-antibodies) or abolished (UM4D4).

Entities: Chemical Gene Species

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Year: 1992 PMID： 1417810 DOI： 10.1016/0006-291x(92)90450-y

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

12 in total

1. Lesional psoriatic T cells contain the capacity to induce a T cell activation molecule CDw60 on normal keratinocytes.

Authors: L Skov; L S Chan; D A Fox; J K Larsen; J J Voorhees; K D Cooper; O Baadsgaard
Journal: Am J Pathol Date: 1997-02 Impact factor: 4.307

2. CDw60: an antigen expressed in many normal tissues and in some tumours.

Authors: A Gocht; A Gadatsch; G Rutter; B Kniep
Journal: Histochem J Date: 2000-07

Review 3. Gangliosides with O-acetylated sialic acids in tumors of neuroectodermal origin.

Authors: Guido Kohla; Eggert Stockfleth; Roland Schauer
Journal: Neurochem Res Date: 2002-08 Impact factor: 3.996

4. Acetylation suppresses the proapoptotic activity of GD3 ganglioside.

Authors: Florence Malisan; Luigi Franchi; Barbara Tomassini; Natascia Ventura; Ivano Condò; Maria Rita Rippo; Alessandra Rufini; Laura Liberati; Claudia Nachtigall; Bernhard Kniep; Roberto Testi
Journal: J Exp Med Date: 2002-12-16 Impact factor: 14.307

10. Costimulation by purified intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 induces distinct proliferation, cytokine and cell surface antigen profiles in human "naive" and "memory" CD4+ T cells.

Authors: R T Semnani; T B Nutman; P Hochman; S Shaw; G A van Seventer
Journal: J Exp Med Date: 1994-12-01 Impact factor: 14.307

CDw 60 antibodies bind to acetylated forms of ganglioside GD3.

1. Lesional psoriatic T cells contain the capacity to induce a T cell activation molecule CDw60 on normal keratinocytes.

2. CDw60: an antigen expressed in many normal tissues and in some tumours.

Review 3. Gangliosides with O-acetylated sialic acids in tumors of neuroectodermal origin.

4. Acetylation suppresses the proapoptotic activity of GD3 ganglioside.

5. 9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate.

Review 6. Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy.

Review 7. Functions and Biosynthesis of O-Acetylated Sialic Acids.

8. Natural ligands of the B cell adhesion molecule CD22 beta can be masked by 9-O-acetylation of sialic acids.

9. CDw60: a marker for human CD8+ T helper cells.

10. Costimulation by purified intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 induces distinct proliferation, cytokine and cell surface antigen profiles in human "naive" and "memory" CD4+ T cells.