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Literature DB >> 14174526

CASE FINDING IN PHENYLKETONURIA. II. THE GUTHRIE TEST.

Abstract

Experience with over 6000 Guthrie tests is presented. This test is a screening procedure for phenylketonuria using small amounts of blood spotted on a filter paper which are tested by a bacterial "inhibition assay". Certain technical aspects of the test (e.g. relation between the concentration of phenylalanine in the blood and extent of the bacterial growth zones produced, type of filter paper, size of the blood spot on the paper) were investigated. It was shown that the Guthrie test clearly distinguishes between subjects with normal plasma phenylalanine levels and patients with untreated phenylketonuria.Applications of the Guthrie test in screening a mental hospital population, admissions to a penitentiary and newborn babies are described.

Entities: Chemical Disease Species

Keywords: BACTERIOLOGICAL TECHNICS; CANADA; DIAGNOSIS, LABORATORY; HOSPITALS; INFANT, NEWBORN, DISEASES; MASS SCREENING; PHENYLALANINE; PHENYLKETONURIA; PRISONS; URINE

Mesh：

Substances：
Phenylalanine

Year: 1964 PMID： 14174526 PMCID： PMC1927280

Source DB: PubMed Journal: Can Med Assoc J ISSN： 0008-4409 Impact factor: 8.262

16 in total

2. Population screening by Guthrie test for phenylketonuria in South-east Scotland. Report by the consultant paediatricians and medical officers of health of the S.E. Scotland Hospital Region.

Authors:
Journal: Br Med J Date: 1968-03-16

3. Case-finding in phenylketonuria: 3. One-way paper chromatography of amino acids in blood.

Authors: M W Partington
Journal: Can Med Assoc J Date: 1968-10-05 Impact factor: 8.262

4. Phenylketonuria-the guthrie screening test-a method of quantitation, observations on reliability and suggestions for improvement.

Authors: C M Blumenfeld; M J Wallace; R Anderson
Journal: Calif Med Date: 1966-12

Review 5. Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications.

Authors: Benjamin S Frey; Deidre E Damon; Abraham K Badu-Tawiah
Journal: Mass Spectrom Rev Date: 2019-09-06 Impact factor: 10.946

5 in total

CASE FINDING IN PHENYLKETONURIA. II. THE GUTHRIE TEST.

1. Cincinnati phenylketonuria detection program--a progress note.

2. Problems of routine screening for phenylketonuria.

3. Atypical phenylketonuria in sisters with normal offspring.

4. Phenylketonuria: screening programs and testing methods.

5. A familial disturbance of histidine metabolism.

6. Minimal media for quantitative studies with Bacillus subtilis.

7. Phenylpyruvic oligophrenia (phenylketonuria).

8. Studies on phenylpyruvic oligophrenia; phenylpyruvic acid content on blood.

9. Assay of L-phenylalanine as phenylethylamine after enzymatic decarboxylation; application to isotopic studies.

10. Variations in intelligence in phenylktonuria.

1. Phenylketonuria. Mass screening of newborns in Ireland.

2. Population screening by Guthrie test for phenylketonuria in South-east Scotland. Report by the consultant paediatricians and medical officers of health of the S.E. Scotland Hospital Region.

3. Case-finding in phenylketonuria: 3. One-way paper chromatography of amino acids in blood.

4. Phenylketonuria-the guthrie screening test-a method of quantitation, observations on reliability and suggestions for improvement.

Review 5. Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications.