Literature DB >> 14173424

SKIN TUMORIGENESIS BY 7,12-DIMETHYLBENZ(A)ANTHRACENE: INHIBITION BY ACTINOMYCIN D.

H V GELBOIN, M KLEIN.   

Abstract

Topical application of actinomycin D during a short period of time immediately before and after a single application of 7, 12-dimethyl-benz (a)anthracene markedly inhibits subsequent tumor formation. The results indicate that the initial events of carcinogenesis are dependent on DNA-dependent RNA synthesis.

Entities:  

Keywords:  ACTINOMYCIN; ANTINEOPLASTIC AGENTS; BENZANTHRACENES; CARCINOGENS; EXPERIMENTAL LAB STUDY; MICE; PHARMACOLOGY; SKIN NEOPLASMS; TOXICOLOGIC REPORT

Mesh：

Substances：

Year:  1964        PMID： 14173424     DOI： 10.1126/science.145.3638.1321

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  3 in total

1.  Proliferative parameters of mammalian cell systms and their rôle in tumor growth and carcinogenesis.

Authors:  M F Rajewsky
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1972

2.  Studies on inhibition of viral oncogenesis. 3. Effect of clam extracts and methotrexate on tumor formation in male and female hamsters induced by virulent and attenuated adenovirus-12.

Authors:  C P Li; N M Tauraso; B Eddy; B Prescott; E C Martino
Journal:  Arch Gesamte Virusforsch       Date:  1972

3.  Inhibition of mouse skin tumorigenesis by actinomycin D.

Authors:  H V Gelboin; M Klein; R R Bates
Journal:  Proc Natl Acad Sci U S A       Date:  1965-06       Impact factor: 11.205
  3 in total

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