Literature DB >> 14173417

PHENETHYL ALCOHOL SYNERGISM WITH MITOMYCIN C, PORFIROMYCIN, AND STREPTONIGRIN.

J R WHITE, H L WHITE.   

Abstract

Cyanide and phenethyl alcohol greatly enhance the lethal action of mitomycin C, porfiromycin, and streptonigrin on an exponentially growing culture of Escherichia coli. Dinitrophenol similarly enhances the lethal action of mitomycin C and porfiromycin, but only slightly that of streptonigrin. Phenethyl alcohol may be functioning in these experiments as an inhibitor of electron transport.

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Keywords:  ALCOHOLS; ANTIBIOTICS; ANTINEOPLASTIC AGENTS; CYANIDES; ESCHERICHIA COLI; EXPERIMENTAL LAB STUDY; MITOMYCIN; PHARMACOLOGY; PHENOLS

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Substances:

Year:  1964        PMID: 14173417     DOI: 10.1126/science.145.3638.1312

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  3 in total

1.  Generation of free radicals from phenazine methosulfate, streptonigrin, and riboflavin in bacterial suspensions.

Authors:  J R White; H H Dearman
Journal:  Proc Natl Acad Sci U S A       Date:  1965-09       Impact factor: 11.205

2.  [Reversible inhibition of the reproduction of virus SV-40 by aromatic alcohols].

Authors:  G Maass; J Hempel
Journal:  Z Med Mikrobiol Immunol       Date:  1966

3.  Evidence for two states of F pili.

Authors:  L Wendt; H W Mobach
Journal:  J Bacteriol       Date:  1969-02       Impact factor: 3.490

  3 in total

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