| Literature DB >> 14172632 |
I FRATTA, S B ZAK, P GREENGARD, E B SIGG.
Abstract
Feeding a diet deficient in nicotinamide, nicotinic acid, and tryptophan to pregnant rats causes death and resorption of all fetuses. This effect can be prevented by administration of either chlorpromazine or imipramine. Analysis of maternal liver at the time of fetal resorption indicates that the observed effects may be mediated through modification of the concentration of the pyridine nucleotide coenzymes.Entities:
Keywords: AVITAMINOSIS; CHLORPROMAZINE; EXPERIMENTAL LAB STUDY; FETAL DEATH; IMIPRAMINE; NAD; NICOTINAMIDE; NICOTINIC ACID; PHARMACOLOGY; PREGNANCY; PREGNANCY, ANIMAL; RATS; TRYPTOPHAN
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Year: 1964 PMID： 14172632 DOI： 10.1126/science.145.3639.1429
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728