Literature DB >> 14172631

HOMOGRAFT TARGET CELLS: SPECIFIC DESTRUCTION IN VITRO BY CONTACT INTERACTION WITH IMMUNE MACROPHAGES.

G A GRANGER, R S WEISER.   

Abstract

Specific adherence and mutual immunologic destruction occurred after contact in vitro of immune peritoneal macrophages from C57BI/6K mice with homograft target cells from A/Jax mice. Cell destruction apparently resulted from a nonphagocytic mechanism involving cell contact rather than humoral antibody. Cell destruction was determined by a plaque technique with either immunecells or target cells as monolayers.

Entities:  

Keywords:  EXPERIMENTAL LAB STUDY; FIBROBLASTS; L CELLS; MACROPHAGES; MICE; PERITONEUM; SARCOMA, EXPERIMENTAL; TISSUE CULTURE; TRANSPLANTATION; TRANSPLANTATION IMMUNOLOGY

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Substances：

Year:  1964        PMID： 14172631     DOI： 10.1126/science.145.3639.1427

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  27 in total

1.  Antibodies-structure and biological function.

Authors:  R R Coombs
Journal:  Proc R Soc Med       Date:  1967-06

2.  Interactions between immunocompetent cells and target cells or antigens.

Authors:  J R David
Journal:  Bull N Y Acad Med       Date:  1967-11

3.  Evidence for compromise of tumour immunity in rats by a non-specific blocking serum factor that inactivates macrophages.

Authors:  R Keller
Journal:  Br J Exp Pathol       Date:  1973-06

4.  Mechanisms by which activated normal macrophages destroy syngeneic rat tumour cells in vitro. Cytokinetics, non-involvement of T lymphocytes, and effect of metabolic inhibitors.

Authors:  R Keller
Journal:  Immunology       Date:  1974-08       Impact factor: 7.397

5.  Macrophage dependent protection of tumour cells.

Authors:  P Hersey; I C MacLennan
Journal:  Immunology       Date:  1973-02       Impact factor: 7.397

6.  In vitro cytotoxicity by human lymphocytes from individuals immunized against histocompatibility antigens. II. Relation to HL-A incompatibility between effector and target cells.

Authors:  G Lundgren; E Möller; E Thorsby
Journal:  Clin Exp Immunol       Date:  1970-05       Impact factor: 4.330

7.  Role of macrophages in tumour immunity. 3. Co-operation between macrophages and lymphoid factors in an in vitro allograft situation.

Authors:  R Evans; C K Grant
Journal:  Immunology       Date:  1972-11       Impact factor: 7.397

8.  Role of macrophages in tumour immunity. I. Co-operation between macrophages and lymphoid cells in syngeneic tumour immunity.

Authors:  R Evans; P Alexander
Journal:  Immunology       Date:  1972-10       Impact factor: 7.397

9.  Mechanisms of target cell destruction by alloimmune peritoneal macrophages. II. Release of a specific cytotoxin from interacting cells.

Authors:  K L McIvor; R S Weiser
Journal:  Immunology       Date:  1971-03       Impact factor: 7.397

10.  Differential effects of human granulocytes and lymphocytes on human fibroblasts in vitro.

Authors:  G Lundgren; C F Zukoski; G Möller
Journal:  Clin Exp Immunol       Date:  1968-10       Impact factor: 4.330
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