Literature DB >> 14172601

ALKYLATION OF SYNTHETIC POLYNUCLEOTIDES.

D B LUDLUM, R C WARNER, A J WAHBA.   

Abstract

The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.

Entities:  

Keywords:  ALKYLATING AGENTS; ALKYLATION; ANTINEOPLASTIC AGENTS; CHEMISTRY; EXPERIMENTAL LAB STUDY; PEPTIDES; POLYNUCLEOTIDES; PROTEIN METABOLISM; SPECTRUM ANALYSIS

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Year:  1964        PMID： 14172601     DOI： 10.1126/science.145.3630.397

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  The molecular basis for biological inactivation of nucleic acids. The action of methylating agents on the ribonucleic acid-containing bacteriophage R17.

Authors:  K V Shooter; R Howse; S A Shah; P D Lawley
Journal:  Biochem J       Date:  1974-02       Impact factor: 3.857

2.  In vivo suppression of coding associated with bacteriophage-induced S-adenosylmethionine hydrolase.

Authors:  P W Siersma; S Lederberg
Journal:  J Bacteriol       Date:  1970-02       Impact factor: 3.490

Review 3.  The RNA-overmethylation in brain tumours. Data and hypothesis.

Authors:  L Perria; G L Viale
Journal:  Acta Neurochir (Wien)       Date:  1969       Impact factor: 2.216

4.  Biochemical patterns in brain tumours. 3. Transfer ribonucleic acid.

Authors:  G L Viale
Journal:  Acta Neurochir (Wien)       Date:  1969       Impact factor: 2.216

5.  Alkylation of polyribonucleotides: the biological, physical, and chemical properties of alkylated polyuridylic acid.

Authors:  C W Abell; L A Rosini; M R Ramseur
Journal:  Proc Natl Acad Sci U S A       Date:  1965-08       Impact factor: 11.205

6.  Effects of a single dose of cyclophosphamide on various organs in the rat. 3. Electron microscopic study of the liver.

Authors:  P Lavin; L G Koss
Journal:  Am J Pathol       Date:  1971-02       Impact factor: 4.307

7.  Chemically induced paramutation at the R locus in maize.

Authors:  J D Axtell; R A Brink
Journal:  Proc Natl Acad Sci U S A       Date:  1967-07       Impact factor: 11.205

8.  Persistence of methylated bases in ribonucleic acid of syrian golden hamster liver after administration of dimethylnitrosamine.

Authors:  G P Margison; J M Margison; R Montesano
Journal:  Biochem J       Date:  1979-03-01       Impact factor: 3.857

9.  Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the hydrogen-bonded structure of ribonucleic acid of brain-cortex ribosomes.

Authors:  R K Datta; J J Ghosh
Journal:  Biochem J       Date:  1970-05       Impact factor: 3.857

10.  Damage induced by methyl methanesulfonate (MMS) in Chlamydomonas reinhardi.

Authors:  R Loppes
Journal:  Z Vererbungsl       Date:  1966
  10 in total

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