Literature DB >> 14171573

PURINE- AND PYRIMIDINE-SPECIFIC ANTIBODIES: EFFECT ON THE FERTILIZED SEA URCHIN EGG.

H S ROSENKRANZ, B F ERLANGER, S W TANENBAUM, S M BEISER.   

Abstract

Antiserums from rabbits immunized with several purine- and pyrimidine-containing albumin conjugates can penetrate and become fixed within cells of Arbacia punctulata. All of these specific antiserums were found to inhibit embryonic development of the fertilized sea urchin egg. The stage of arrestment of development was dependent in part upon the dilution of antiserum, and also upon the nature of its specificity. It is suggested that the observed results reflect the interaction of these antiserums with singlestranded DNA within the cell.

Entities:  

Keywords:  ANTIBODIES; ECHINODERMATA; EXPERIMENTAL LAB STUDY; IMMUNE SERUMS; OVUM; PURINES; PYRIMIDINES; RABBITS

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Substances：

Year:  1964        PMID： 14171573     DOI： 10.1126/science.145.3629.282

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Antibodies to hapten-conjugated proteins which cross-react with RNA.

Authors:  M H Karol; S W Tanenbaum
Journal:  Proc Natl Acad Sci U S A       Date:  1967-03       Impact factor: 11.205

2.  Effect of antibodies against DNA on hematopoietic stem cells.

Authors:  V K Podgorodnichenko; A G Konoplyannikov; O V Semina; A M Poverennyi
Journal:  Bull Exp Biol Med       Date:  1974-10       Impact factor: 0.804

Review 3.  B cells and autoantibodies in the pathogenesis of lupus nephritis.

Authors:  M P Madaio
Journal:  Immunol Res       Date:  1998       Impact factor: 2.829

4.  Antibody penetration into living cells. I. Intranuclear immunoglobulin in peripheral blood mononuclear cells in mixed connective tissue disease and systemic lupus erythematosus.

Authors:  D Alarcón-Segovia; A Ruíz-Argüelles; E Fishbein
Journal:  Clin Exp Immunol       Date:  1979-03       Impact factor: 4.330

5.  In vitro effect of antibodies to DNA on the template activity of DNA.

Authors:  J N Whitaker; J L Starr
Journal:  J Clin Invest       Date:  1968-07       Impact factor: 14.808

6.  Nuclear fluorescence employing antinucleoside immunoglobulins.

Authors:  W J Klein; S M Beiser; B F Erlanger
Journal:  J Exp Med       Date:  1967-01-01       Impact factor: 14.307

7.  A STUDY OF THE CROSS-REACTIVITY OF ANTIPURIN-6-OYL SERUM WITH DEOXYRIBONUCLEIC ACID (DNA).

Authors:  V P BUTLER; S W TANENBAUM; S M BEISER
Journal:  J Exp Med       Date:  1965-01-01       Impact factor: 14.307
  7 in total

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