Literature DB >> 14171570

URACIL: FAILURE TO RESTORE DNA SYNTHESIS WHILE RELIEVING 5-FLUOROURACIL-INDUCED INHIBITION.

M REICH, H G MANDEL.   

Abstract

Growth inhibition of Bacillus cereus by 5-fluorouracil is abolished by the addition of uracil without the inhibition of DNA synthesis being relieved. The growth rate, protein, and RNA content of cells grown in the presence of 5-fluorouracil and uracil are unaffected until the cells contain only about 25 percent of their normal DNA content.

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Keywords:  ADENINE; BACILLUS CEREUS; CARBON ISOTOPES; DNA, BACTERIAL; EXPERIMENTAL LAB STUDY; FLUOROURACIL; FORMATES; GUANINE; HYPOXANTHINES; METABOLISM; PHARMACOLOGY; URACIL

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Year:  1964        PMID: 14171570     DOI: 10.1126/science.145.3629.276

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  3 in total

1.  Nucleic acids and protein biosynthesis during alkylation with triethylenemelamine in kb-cells.

Authors:  S Comorosan; S Vieru; A Gaspar; D Sandru
Journal:  Z Krebsforsch       Date:  1968

2.  Dissociation of cellular functions in Bacillus cereus by 5-fluorouracil.

Authors:  M Reich; H G Mandel
Journal:  J Bacteriol       Date:  1966-02       Impact factor: 3.490

3.  Use of fluorouracil-uracil combinations to study growth accompanied by insufficient deoxyribonucleic acid synthesis in Bacillus cereus.

Authors:  C H Doolittle; H G Mandel; G A Hahn
Journal:  J Bacteriol       Date:  1973-03       Impact factor: 3.490

  3 in total

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