Literature DB >> 14171555

GAMMA GLOBULIN: UNMASKING OF HIDDEN ANTIGENIC SITES ON LIGHT CHAINS.

R L NACHMAN, R L ENGLE.   

Abstract

Normal light (L) chains cleaved from normal pooled human gamma globulin contain immunologic determinants not overtly present in the native unreduced molecule. These hidden determinants are shared with Bence Jones proteins. Similarly, one of two Bence Jones proteins contained immunologic determinants which were not overtly present on the autologous serum myeloma protein.

Entities:  

Keywords:  ANTIGENS; BENCE JONES PROTEIN; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN; GEL DIFFUSION TESTS; PRECIPITIN TESTS

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Year:  1964        PMID： 14171555     DOI： 10.1126/science.145.3628.167

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  Serum and urine light chain levels in benign monoclonal gammapathies, multiple myeloma and Waldenström's macroglobulinaemia.

Authors:  F Dammacco; J Waldenström
Journal:  Clin Exp Immunol       Date:  1968-11       Impact factor: 4.330

2.  A hereditary immunoglobulin A abnormality: absence of light-heavy-chain assembly. Study of immunoglobulin synthesis in tonsillar cells.

Authors:  C Moroz; J Amir; A De Vries
Journal:  J Clin Invest       Date:  1971-12       Impact factor: 14.808

3.  A NEW CLASS OF HUMAN IMMUNOGLOBULINS. II. NORMAL SERUM IGD.

Authors:  D S ROWE; J L FAHEY
Journal:  J Exp Med       Date:  1965-01-01       Impact factor: 14.307

4.  INDIVIDUAL ANTIGENIC SPECIFICITY OF MYELOMA PROTEINS. CHARACTERISTICS AND LOCALIZATION TO SUBUNITS.

Authors:  H M GREY; M MANNIK; H G KUNKEL
Journal:  J Exp Med       Date:  1965-04-01       Impact factor: 14.307
  4 in total

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