Literature DB >> 1417070

Induction and repair of UVB-induced cyclobutane pyrimidine dimers and (6-4) photoproducts in organ-cultured normal human skin.

T Muramatsu1, N Kobayashi, H Tada, M Yamaji, T Shirai, T Mori, T Ohnishi.   

Abstract

To examine the induction and repair of UV-induced DNA damage, indirect immunofluorescence was performed on UVB-irradiated organ-cultured normal human skin using monoclonal antibodies specific for either cyclobutane pyrimidine dimers or (6-4) photoproducts. Nuclear immunofluorescence of cyclobutane pyrimidine dimers and (6-4) photoproducts were observed in a dose-dependent manner after UVB irradiation. The intensity of nuclear immunofluorescence of the upper epidermal layers was stronger and clearer than that of the lower epidermal layers. DNA repair time-course studies showed that both types of DNA damage could be repaired within 24 h after UVB irradiation.

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Year:  1992        PMID： 1417070     DOI： 10.1007/bf00375800

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  26 in total

1.  Detection of photorepair of UV-induced thymine dimers in human epidermis by immunofluorescence microscopy.

Authors:  L Roza; F R De Gruijl; J B Bergen Henegouwen; K Guikers; H Van Weelden; G P Van Der Schans; R A Baan
Journal:  J Invest Dermatol       Date:  1991-06       Impact factor: 8.551

2.  In situ (6-4)photoproduct determination by laser cytometry and autoradiography.

Authors:  T Mori; T Matsunaga; C C Chang; J E Trosko; O Nikaido
Journal:  Mutat Res       Date:  1990-07       Impact factor: 2.433

3.  Variations in excision repair of UVB-induced pyrimidine dimers in DNA of human skin in situ.

Authors:  S E Freeman
Journal:  J Invest Dermatol       Date:  1988-06       Impact factor: 8.551

4.  The relative cytotoxicity of (6-4) photoproducts and cyclobutane dimers in mammalian cells.

Authors:  D L Mitchell
Journal:  Photochem Photobiol       Date:  1988-07       Impact factor: 3.421

Review 5.  Xeroderma pigmentosum.

Authors:  E G Jung
Journal:  Int J Dermatol       Date:  1986-12       Impact factor: 2.736

6.  U.v.-induced DNA damage and its repair in human skin in vivo studied by sensitive immunohistochemical methods.

Authors:  G Eggset; G Volden; H Krokan
Journal:  Carcinogenesis       Date:  1983       Impact factor: 4.944

7.  Use of high-performance liquid chromatography to quantitate thymine-containing pyrimidine dimers in DNA.

Authors:  J D Love; E C Friedberg
Journal:  J Chromatogr       Date:  1982-05-21

8.  Repair of pyrimidine(6-4)pyrimidone photoproducts in mouse skin.

Authors:  D L Mitchell; J E Cleaver; J H Epstein
Journal:  J Invest Dermatol       Date:  1990-07       Impact factor: 8.551

9.  Pyrimidine dimer formation and repair in human skin.

Authors:  B M Sutherland; L C Harber; I E Kochevar
Journal:  Cancer Res       Date:  1980-09       Impact factor: 12.701

10.  Comparative studies on photoreactivation of ultraviolet light-induced T4 endonuclease susceptible sites and sister-chromatid exchanges in Potorous cells.

Authors:  K Ishizaki; H Takebe
Journal:  Mutat Res       Date:  1985 Jun-Jul       Impact factor: 2.433
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  2 in total

1.  UVB irradiation reduces the expression of pemphigoid antigens in organ-cultured normal human skin.

Authors:  T Muramatsu; Y Yamashina; T Shirai; T Ohnishi
Journal:  Arch Dermatol Res       Date:  1994       Impact factor: 3.017

2.  Quantitative detection of ultraviolet light-induced photoproducts in mouse skin by immunohistochemistry.

Authors:  X Qin; S Zhang; H Oda; Y Nakatsuru; S Shimizu; Y Yamazaki; O Nikaido; T Ishikawa
Journal:  Jpn J Cancer Res       Date:  1995-11
  2 in total

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