SEX-ASSOCIATED DIFFERENCES IN SERUM PROTEINS OF MICE.

Agar electrophoresis of serum from mice of C57BL/10-H-2(d), B10.Sn, A.SW, A.CA, R III, and P1 inbred strains shows that the females have a lower concentration of alpha-1 serum globulin than the males and, in some strains, the females also have a lower concentration of alpha-2 and, beta-serum globulin. Females of the A.SW strain have a higher serum albumin concentration than males, and females of the C57BL/10-H-2(d) strain have a higher gamma-globulin concentration than males. Two-dimensional (agar and hydrolyzed-starch) electrophoresis gives a typical sex-associated pattern for alpha-1 and alpha-2 globulins which clearly permits recognition of male and female serums.