Dynamic metabolic control theory. A methodology for investigating metabolic regulation using transient metabolic data.

The purposes of the dynamic metabolic control theory are to provide a theoretical basis for estimating the control coefficients using the transient metabolic responses and to gain insights into the metabolic regulation in the transient states. The numerical application of this theory is relatively straightforward: it involves a standard linear regression and a matrix multiplication. Although the equations are exact only for linear kinetics, they yield relatively good estimates of the control coefficients for nonlinear systems.