| Literature DB >> 14163812 |
Abstract
Actinomycin D inhibits vitamin K induced formation of prothrombin in chicks deficient in vitamin K. The administration of actinomycin in doses which inhibit prothrombin formation also inhibits synthesis in the liver of RNA from adenosine triphosphate as detected with adenine-8-C1(4). The results are consistent with a genetic action of vitamin K in inducing RNA formation for the synthesis of clotting proteinsEntities:
Keywords: ACTINOMYCIN; ADENINE; ADENINE NUCLEOTIDES; ADENOSINE TRIPHOSPHATE; ANTIMETABOLITES; CARBON ISOTOPES; EXPERIMENTAL LAB STUDY; LIVER; METABOLISM; NAPHTHOQUINONES; PHARMACOLOGY; POULTRY; PROTEIN METABOLISM; PROTHROMBIN TIME; RNA; VITAMIN K DEFICIENCY
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Year: 1964 PMID： 14163812 DOI： 10.1126/science.145.3635.926
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728