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Literature DB >> 14163789

HUMAN ERYTHROCYTE LACTATE DEHYDROGENASE: 4 GENETICALLY DETERMINED VARIANTS.

Abstract

Four variants of human erythrocyte lactate dehydrogenase (LDH) are described. One of these is similar to the one previously described by Boyer and is interpreted as a variant of LDH-B. The other three are thought to represent variants of LDH-A. Studies of families indicate that LDH-A and LDH-B are under separate genetic control and are inherited as autosomal co-dominants. Evidence is presented that the LDH-A locus is not closely linked to the loci for the ABH and Duffy blood group systems.

Entities: Gene Species

Keywords: CLINICAL RESEARCH; ELECTROPHORESIS; ERYTHROCYTES; GENETICS, HUMAN; LACTATE DEHYDROGENASE

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Year: 1964 PMID： 14163789 DOI： 10.1126/science.145.3632.595

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

17 in total

1. The thin-layer isoelectric focusing of lactate dehydrogenase isoenzymes in rabbit lens parts and in intraocular tissues.

Authors: J Bours; H Neuhaus; O Hockwin
Journal: Albrecht Von Graefes Arch Klin Exp Ophthalmol Date: 1977-07-08

10. [Studies on the pattern and distribution of enzymes in the nucous membrane of the gastrointestinal tract. 3. Electrophoretic characterization of enzymes of the mucous membrane of the stomach, small intestine, and rectum occurring in multiple forms and comparative serum analyses].

Authors: U E Klein; H C Drube; H T Hansen; H Mielke
Journal: Klin Wochenschr Date: 1967-03-01

HUMAN ERYTHROCYTE LACTATE DEHYDROGENASE: 4 GENETICALLY DETERMINED VARIANTS.

1. The thin-layer isoelectric focusing of lactate dehydrogenase isoenzymes in rabbit lens parts and in intraocular tissues.

2. Two further cases of homozygosity for a lactate dehydrogenase variant gene.

3. Genetic polymorphisms in Kenya.

4. Caste and age variations of the incidence of LDH variants in the Bengali Hindus.

5. Multiple lactate dehydrogenase alleles in the lizard Agama stellio.

6. A genetically determined variant of the A-subunit of lactic dehydrogenase in the deer mouse.

7. Evolutionary evidence for a regulator gene controlling the lactate dehydrogenase B gene in rodent erythrocytes.

8. Use of blood clots as enzyme source in gel electrophoresis.

9. A genetically controlled lactate dehydrogenase variant at the B locus in mink.

10. [Studies on the pattern and distribution of enzymes in the nucous membrane of the gastrointestinal tract. 3. Electrophoretic characterization of enzymes of the mucous membrane of the stomach, small intestine, and rectum occurring in multiple forms and comparative serum analyses].