Literature DB >> 14163782

DIFFERENTIAL ESTIMATION OF GAMMA-BUTYROLACTONE AND GAMMA-HYDROXYBUTYRIC ACID IN RAT BLOOD AND BRAIN.

N J GIARMAN, R H ROTH.   

Abstract

A sensitive and specific gas chromatographic technique for estimating concentrations of the anesthetic adjuvants, gamma-butyrolactone and gamma-hydroxybutyrate, in tissues has been developed. These substances do not appear to occur endogenously in either the blood or the brain of common laboratory animals. The onset and duration of anesthesia caused by the administration of either compound is correlated with the concentration of gamma-hydroxybutyrate in the brain, rather than with that of the corresponding lactone.

Entities:  

Keywords:  ANESTHESIA, INTRAVENOUS; BLOOD CHEMICAL ANALYSIS; BRAIN; CATS; CHROMATOGRAPHY; DOGS; EXPERIMENTAL LAB STUDY; HYDROXYBUTYRATES; LACTONES; NEUROCHEMISTRY; PHARMACOLOGY; RABBITS; RATS; SERUM ALBUMIN, RADIO-IODINATED

Mesh：

Substances：

Year:  1964        PMID： 14163782     DOI： 10.1126/science.145.3632.583

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

1.  Potential gamma-hydroxybutyric acid (GHB) drug interactions through blood-brain barrier transport inhibition: a pharmacokinetic simulation-based evaluation.

Authors:  Indranil Bhattacharya; Kathleen M K Boje
Journal:  J Pharmacokinet Pharmacodyn       Date:  2006-08-29       Impact factor: 2.745

2.  Impact of strain, sex, and estrous cycle on gamma butyrolactone-evoked absence seizures in rats.

Authors:  Victor R Santos; Ihori Kobayashi; Robert Hammack; Gregory Danko; Patrick A Forcelli
Journal:  Epilepsy Res       Date:  2018-09-18       Impact factor: 3.045

3.  Dopaminergic inhibition of striatal cholinergic neurons: synergistic blocking action of gamma-butyrolactone and neuroleptic drugs.

Authors:  H Stadler; K G Lloyd; G Bartholini
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

4.  Gamma-hydroxybutyric acid and sleep.

Authors:  C Mitoma; S E Neubauer
Journal:  Experientia       Date:  1968-01-15

5.  Effects of dopamine agonists, catecholamine depletors, and cholinergic and GABAergic drugs on acute dyskinesias in squirrel monkeys.

Authors:  R Neale; S Gerhardt; J M Liebman
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

6.  Pharmacokinetics of gamma-hydroxybutyric acid in alcohol dependent patients after single and repeated oral doses.

Authors:  S D Ferrara; S Zotti; L Tedeschi; G Frison; F Castagna; L Gallimberti; G L Gessa; P Palatini
Journal:  Br J Clin Pharmacol       Date:  1992-09       Impact factor: 4.335

7.  Evidence for down-regulation of GABA receptors following long-term gamma-butyrolactone.

Authors:  G Gianutsos; P D Suzdak
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-11       Impact factor: 3.000

8.  The metabolism of potassium dodecyl [35-S]sulphate in the rat.

Authors:  W H Denner; A H Olavesen; G M Powell; K S Dodgson
Journal:  Biochem J       Date:  1969-01       Impact factor: 3.857

9.  Mode of action of gamma-butyrolactone on the central cholinergic system.

Authors:  H Ladinsky; S Consolo; A Zatta; A Vezzani
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-02       Impact factor: 3.000

10.  Effects of monocarboxylate transporter inhibition on the oral toxicokinetics/toxicodynamics of γ-hydroxybutyrate and γ-butyrolactone.

Authors:  Bridget L Morse; Marilyn E Morris
Journal:  J Pharmacol Exp Ther       Date:  2013-02-07       Impact factor: 4.030
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