| Literature DB >> 14163768 |
M D GARRICK, H ELBERFELD, S R SUSKIND.
Abstract
In addition to indole-3-glycerolphosphate, an unreported reaction product has been detected in incubation mixtures containing tryptophan synthetase from Neurospora, indole, and glyceraldehyde-3-phosphate. This product has been tentatively identified as an indole derivative. Since this compound is not formed in incubation mixtures initially containing only enzyme and indole-3-glycerolphosphate, it was concluded that indole-3-glycerolphosphate synthesis and breakdown are not simply the forward and reverse components of a reversible reaction.Entities:
Keywords: CHROMATOGRAPHY; EXPERIMENTAL LAB STUDY; GLYCEROPHOSPHATES; HYDRO-LYASES; INDOLES; METABOLISM; MUTATION; NEUROSPORA; TRYPTOPHAN
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Year: 1964 PMID： 14163768 DOI： 10.1126/science.145.3631.491
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728