Literature DB >> 14163329

TUMOR-PROMOTING ACTIVITY OF EXTRACTS OF UNBURNED TOBACCO.

F G BOCK, G E MOORE, S K CROUCH.   

Abstract

Both an aqueous Balpha(OH)(2) extract and an acetone-benzene extract of unburned cigarette tobacco produced skin tumors when painted on mice previously treated with 125 microg of7,12-dimethylbenz[a]anthracene. The extract from as little as 0.5 cigarette per day was effective. The data are of interest in connection with epidemiological evidence that tobacco chewing is a cause of oral cancer. The data also suggest that tumor-promoting agents in cigarette smokemay have their source in the unburned tobacco

Entities:  

Keywords:  BARIUM; BENZANTHRACENES; CARCINOGENS; EXPERIMENTAL LAB STUDY; HYDROXIDES; MICE; MOUTH NEOPLASMS; NEOPLASMS, EXPERIMENTAL; PAPILLOMA; PHARMACOLOGY; SKIN NEOPLASMS; TISSUE EXTRACTS; TOBACCO

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Year:  1964        PMID： 14163329     DOI： 10.1126/science.145.3634.831

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

Review 1.  Health consequences of using smokeless tobacco: summary of the Advisory Committee's report to the Surgeon General.

Authors:  J W Cullen; W Blot; J Henningfield; G Boyd; R Mecklenburg; M M Massey
Journal:  Public Health Rep       Date:  1986 Jul-Aug       Impact factor: 2.792

2.  [Experimental studies on tumorigenic activity of cigarette smoke condensate in mouse skin. I. Total experiment].

Authors:  W Dontenwill; H Elmenhorst; H P Harke; G Reckzeh; K H Weber; J Misfeld; J Timm
Journal:  Z Krebsforsch       Date:  1970

3.  Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes.

Authors:  Vishalakshi Nanjappa; Santosh Renuse; Gajanan J Sathe; Remya Raja; Nazia Syed; Aneesha Radhakrishnan; Tejaswini Subbannayya; Arun Patil; Arivusudar Marimuthu; Nandini A Sahasrabuddhe; Rafael Guerrero-Preston; Babu L Somani; Bipin Nair; Gopal C Kundu; T Keshava Prasad; Joseph A Califano; Harsha Gowda; David Sidransky; Akhilesh Pandey; Aditi Chatterjee
Journal:  Cancer Biol Ther       Date:  2015-09-21       Impact factor: 4.742

4.  Skin-tumour-promoting activity of processed bidi tobacco in hairless S/RV Cri-ba mice.

Authors:  A N Bagwe; A G Ramchandani; R A Bhisey
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

5.  Chronic cigarette smoke extract treatment selects for apoptotic dysfunction and mitochondrial mutations in minimally transformed oral keratinocytes.

Authors:  Steven S Chang; Wei Wen Jiang; Ian Smith; Chad Glazer; Wen-Yue Sun; Suhail Mithani; Joseph A Califano
Journal:  Int J Cancer       Date:  2010-01-01       Impact factor: 7.396

6.  Evaluation of cytomorphometric changes in tobacco users and diagnosed oral squamous cell carcinoma individuals.

Authors:  Urmila Udayashankar; Vijay Srinivas Guduru; Anuradha Ananthaneni; Sabitha Devi Ramisetty; Puneeth Horatti Kuberappa; Srilekha Namala
Journal:  J Cytol       Date:  2016 Jul-Sep       Impact factor: 1.000
  6 in total

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