Literature DB >> 14163327

RELEASE OF METARAMINOL (ARAMINE) FROM THE HEART BY SYMPATHETIC NERVE STIMULATION.

J R CROUT, H S ALPERS, E L TATUM, P A SHORE.   

Abstract

Cats were injected intravenously with metaraminol, an amine which depletes norepinephrine from the sympathetic nerve endings; their hearts were then perfused in vitro. Stimulation of the sympathetic nerve supply released metaraminol from the hearts, demonstrating that a synthetic compound can replace norepinephrine and serve as a transmitter at adrenergic nerve endings

Entities:  

Keywords:  CATS; EXPERIMENTAL LAB STUDY; METARAMINOL; MYOCARDIUM; NOREPINEPHRINE; PHARMACOLOGY; SYMPATHETIC NERVOUS SYSTEM

Mesh：

Substances：

Year:  1964        PMID： 14163327     DOI： 10.1126/science.145.3634.828

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  On the mechanism of action of clozapine on the adrenergic neurone.

Authors:  R L Dorris; P A Shore
Journal:  Br J Pharmacol       Date:  1976-03       Impact factor: 8.739

2.  Differences in amine storage in rat heart and brain.

Authors:  S J Enna; P A Shore
Journal:  Br J Pharmacol       Date:  1974-02       Impact factor: 8.739

Review 3.  Pressor agents.

Authors:  N T Smith
Journal:  Calif Med       Date:  1967-07

4.  Restoration of the response to tyramine by metaraminol in reserpinized cats.

Authors:  B Bhagat; G Bovell; R Ragland
Journal:  Br J Pharmacol Chemother       Date:  1966-02

5.  The influence of cold exposure on the in vivo release of metaraminol.

Authors:  G E Johnson; D Mickle
Journal:  Br J Pharmacol Chemother       Date:  1966-11

6.  Effect of reserpine and protriptyline on the subcellular distribution of 3H-metaraminol in the mouse heart.

Authors:  P Lundborg; R E Stitzel
Journal:  Br J Pharmacol Chemother       Date:  1967-06

7.  The effect of stimulation of sympathetic nerves in the cat treated with reserpine, alpha-methyldopa and alpha-methylmetatyrosine.

Authors:  W Haefely; A Hürlimann; H Thoenen
Journal:  Br J Pharmacol Chemother       Date:  1966-01

8.  Effects of chronic metaraminol treatment on the sympathetic activity of intact and adrenal demedullated rats kept in warm or cold environments.

Authors:  G E Johnson; T A Pugsley
Journal:  Br J Pharmacol       Date:  1970-11       Impact factor: 8.739

9.  Studies on the interrelationship between the syntheses of noradrenaline and metaraminol.

Authors:  G E Johnson; T A Pugsley
Journal:  Br J Pharmacol       Date:  1970-05       Impact factor: 8.739

10.  The formation and release of metaraminol during exposure to warm or cold environments.

Authors:  G E Johnson; T A Pugsley
Journal:  Br J Pharmacol       Date:  1968-10       Impact factor: 8.739
  10 in total

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