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Literature DB >> 14163324

MACROGLOBULIN FROM HUMAN PLASMA WHICH FORMS AN ENZYMATICALLY ACTIVE COMPOUND WITH TRYPSIN.

Abstract

The protein from human plasma which forms an enzymatically active complex with trypsin and is able to protect trypsin from inhibition by soybean trypsin inhibitor has been shown to be an alpha(2)-macroglobulin. It was obtained from the lipid-poor euglobulin of Cohn Fraction III-0, and appears to be closely related to the 19S-glycoprotein or alpha(2)macroglobulin

Entities: Chemical Species

Keywords: ALPHA GLOBULIN; BLOOD PROTEIN ELECTROPHORESIS; CHROMATOGRAPHY; DIALYSIS; ENZYME INHIBITORS; EXPERIMENTAL LAB STUDY; SERUM GLOBULINS; TRYPSIN

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Substances：

Year: 1964 PMID： 14163324 DOI： 10.1126/science.145.3634.821

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

28 in total

7. A proposed role for alpha1 macroglobulin in the promotion of alpha1 acute-phase globulin synthesis by the perfused rat liver.

Authors: J Metcalfe; A S Tavill
Journal: Br J Exp Pathol Date: 1975-12

8. Studies on the ascites fluid of acute pancreatitis in man.

Authors: M C Geokas; H Rinderknecht; J W Brodrick; C Largman
Journal: Am J Dig Dis Date: 1978-02

9. Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon model.

Authors: J P de Boer; A A Creasey; A Chang; J J Abbink; D Roem; A J Eerenberg; C E Hack; F B Taylor
Journal: Infect Immun Date: 1993-12 Impact factor: 3.441

10. Inhibitors of kallikrein in human plasma.

Authors: D J McConnell
Journal: J Clin Invest Date: 1972-07 Impact factor: 14.808

MACROGLOBULIN FROM HUMAN PLASMA WHICH FORMS AN ENZYMATICALLY ACTIVE COMPOUND WITH TRYPSIN.

1. Proteolytic enzyme activity in patients with severe head injury and the effect of a proteinase inhibitor.

2. Inactivation of human interleukin-2 (IL-2) by alpha 2-macroglobulin-trypsin complexes.

3. A four-straight-line model for the proteinase-binding characteristics of human blood serum.

4. Degradation of human fibrinogen by plasms alpha2-macroglobulin-enzyme complexes.

5. Phenogroups and quantitative allelic expression for rabbit serum 2 -macroglobulin allotypes.

6. Characterization of a human serum inhibitor of Clostridium histolyticum proteinase(s).

7. A proposed role for alpha1 macroglobulin in the promotion of alpha1 acute-phase globulin synthesis by the perfused rat liver.

8. Studies on the ascites fluid of acute pancreatitis in man.

9. Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon model.

10. Inhibitors of kallikrein in human plasma.