Literature DB >> 14163322

NICOTONIC ACID BIOSYNTHESIS: CONTROL BY AN ENZYME THAT COMPETES WITH A SPONTANEOUS REACTION.

A H MEHLER, K YANO, E L MAY.   

Abstract

Extracts of livers from diabetic rats contain normal amounts of the enzymes needed to convert 3-hydroxyanthranilic acid to nicotinic acid nucleotide. The decreased capacity of diabetic animals to synthesize nicotinic acid is therefore attributed to increased amounts of picolinic carboxylase, which competes for a common intermediate with the spontaneous reaction in which quinolinic acid is formed as a precursor of nicotinic acid. These studies were facilitated by the synthesis of 3-hydroxyanthranilic acid labeled with carbon-14 in positions 3 and 6

Entities:  

Keywords:  ADENOSINE TRIPHOSPHATE; ALLOXAN DIABETES; ANTHRANILIC ACID; CARBON DIOXIDE; CARBON ISOTOPES; CARBOXY-LYASES; EXPERIMENTAL LAB STUDY; LIVER ENZYMOLOGY; LIVER EXTRACTS; MANOMETRY; METABOLISM; NICOTINIC ACID; OXIDOREDUCTASES; PHARMACOLOGY; PYRIDINES; PYROPHOSPHATES; RATS

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Substances：

Year:  1964        PMID： 14163322     DOI： 10.1126/science.145.3634.817

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  The power of two: arginine 51 and arginine 239* from a neighboring subunit are essential for catalysis in α-amino-β-carboxymuconate-epsilon-semialdehyde decarboxylase.

Authors:  Lu Huo; Ian Davis; Lirong Chen; Aimin Liu
Journal:  J Biol Chem       Date:  2013-09-09       Impact factor: 5.157

2.  Improved separation and detection of picolinic acid and quinolinic acid by capillary electrophoresis-mass spectrometry: application to analysis of human cerebrospinal fluid.

Authors:  Xiaochun Wang; Ian Davis; Aimin Liu; Andrew Miller; Shahab A Shamsi
Journal:  J Chromatogr A       Date:  2013-10-02       Impact factor: 4.759

3.  Charge Maintenance during Catalysis in Nonheme Iron Oxygenases.

Authors:  Ephrahime S Traore; Aimin Liu
Journal:  ACS Catal       Date:  2022-05-10       Impact factor: 13.700

4.  The role of tryptophan 2,3-dioxygenase in the hormonal control of tryptophan metabolism in isolated rat liver cells. Effects of glucocorticoids and experimental diabetes.

Authors:  M Salter; C I Pogson
Journal:  Biochem J       Date:  1985-07-15       Impact factor: 3.857

5.  Evidence for a dual role of an active site histidine in α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase.

Authors:  Lu Huo; Andrew J Fielding; Yan Chen; Tingfeng Li; Hiroaki Iwaki; Jonathan P Hosler; Lirong Chen; Yoshie Hasegawa; Lawrence Que; Aimin Liu
Journal:  Biochemistry       Date:  2012-07-12       Impact factor: 3.162

6.  Tryptophan and glucose metabolism in rat liver cells. The effects of DL-6-chlorotryptophan, 4-chloro-3-hydroxyanthranilate and pyrazinamide.

Authors:  J S Cook; C I Pogson
Journal:  Biochem J       Date:  1983-08-15       Impact factor: 3.857

7.  Development of a CZE-ESI-MS assay with a sulfonated capillary for profiling picolinic acid and quinolinic acid formation in multienzyme system.

Authors:  Xiaochun Wang; Ian Davis; Aimin Liu; Shahab A Shamsi
Journal:  Electrophoresis       Date:  2013-05-23       Impact factor: 3.535

8.  Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD+ Synthesis During Inflammation and Infection.

Authors:  John R Moffett; Peethambaran Arun; Narayanan Puthillathu; Ranjini Vengilote; John A Ives; Abdulla A-B Badawy; Aryan M Namboodiri
Journal:  Front Immunol       Date:  2020-02-21       Impact factor: 7.561
  8 in total

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