Literature DB >> 14162694

PYRUVATE METABOLISM AND CONTROL: FACTORS AFFECTING PYRUVIC CARBOXYLASE ACTIVITY.

A D FREEDMAN, L KOHN.   

Abstract

Pyruvic carboxylase activated by acetyl coenzyme A is highly active in the mitochondria of rodent liver, and its activity is increased in fasting and alloxan diabetes. In conjunction with acyl carboxylase activated by di- and tricarboxylic acid, it forms a reciprocating control network. Analog models of similar networks tend to correct for perturbations, stabilizing the overall system.

Entities:  

Keywords:  ALLOXAN DIABETES; AUTOMATIC DATA PROCESSING; CARBON DIOXIDE; CARBON ISOTOPES; COENZYME A; EXPERIMENTAL LAB STUDY; FASTING; INSULIN, PROTAMINE ZINC; LIGASES; LIVER CYTOLOGY; LIVER ENZYMOLOGY; MICE; MITOCHONDRIA; PYRUVATES; RATS; TOXICOLOGIC REPORT

Mesh：

Substances：

Year:  1964        PMID： 14162694     DOI： 10.1126/science.145.3627.58

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  INSULIN: SUPPRESSOR OF BIOSYNTHESIS OF HEPATIC GLUCONEOGENIC ENZYMES.

Authors:  G WEBER; R L SINGHAL; S K SRIVASTAVA
Journal:  Proc Natl Acad Sci U S A       Date:  1965-01       Impact factor: 11.205

2.  Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver.

Authors:  F J Ballard; R W Hanson
Journal:  Biochem J       Date:  1967-09       Impact factor: 3.857

3.  Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins.

Authors:  Wenwei Zhang; So Young Bu; Mara T Mashek; InSug O-Sullivan; Zakaria Sibai; Salmaan A Khan; Olga Ilkayeva; Christopher B Newgard; Douglas G Mashek; Terry G Unterman
Journal:  Cell Rep       Date:  2016-03-31       Impact factor: 9.423

4.  Amino acid metabolism during prolonged starvation.

Authors:  P Felig; O E Owen; J Wahren; G F Cahill
Journal:  J Clin Invest       Date:  1969-03       Impact factor: 14.808

5.  Paths of carbon in gluconeogenesis and lipogenesis: the role of mitochondria in supplying precursors of phosphoenolpyruvate.

Authors:  H A Lardy; V Paetkau; P Walter
Journal:  Proc Natl Acad Sci U S A       Date:  1965-06       Impact factor: 11.205

6.  [The effect of insulin on the metabolism of isolated perfused livers of normal and alloxan-diabetic rats. I. The metabolism of isolated perfused livers in normal and alloxan-diabetic rats under various experimental conditions].

Authors:  H D Söling; R Koschel; W Drägert; P Kneer; W Creutzfeldt
Journal:  Diabetologia       Date:  1966-06       Impact factor: 10.122

7.  Studies on gluconeogenesis, protein synthesis and cyclic AMP levels in isolated hepatocytes from alloxan diabetic rats.

Authors:  S R Wagle; W R Ingebretsen; L Sampson
Journal:  Diabetologia       Date:  1975-10       Impact factor: 10.122

8.  Effect of streptozotocin-induced diabetes mellitus on the turnover of rat liver pyruvate carboxylase and pyruvate dehydrogenase.

Authors:  M B Weinberg; M F Utter
Journal:  Biochem J       Date:  1980-06-15       Impact factor: 3.857

9.  Regulation of gluconeogenesis and lipogenesis. The regulation of mitochondrial pyruvate metabolism in guinea-pig liver synthesizing precursors for gluconeogenesis.

Authors:  E W Somberg; M A Mehlman
Journal:  Biochem J       Date:  1969-05       Impact factor: 3.857
  9 in total

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