| Literature DB >> 14150328 |
C T RUDKIN, D A HUNGERFORD, P C NOWELL.
Abstract
The Philadelphia chromosome, characteristic of chronic granulocytic leukemia, contained 61+/-1 percent as much DNA as a number 21 (or 22) chromosome from which it is believed to be derived. The remaining 39 percent represents 0.5 percent of a diploid chromosome complement, approximately 2 x 10(7) nucleotide pairs; the method used was not sensitive enough to detect whether it had been translocated to other chromosomes.Entities:
Keywords: CELL NUCLEUS; CHROMOSOMES; DNA, NEOPLASM; GENETICS; LEUKEMIA, MYELOCYTIC; PATHOLOGY
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Year: 1964 PMID： 14150328 DOI： 10.1126/science.144.3623.1229
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728