Literature DB >> 14149398

IMMUNOLOGICAL TOLERANCE INDUCED IN ANIMALS PREVIOUSLY SENSITIZED TO SIMPLE CHEMICAL COMPOUNDS.

J R FREY, H GELEICK, A DEWECK.   

Abstract

Adult guinea pigs develop a delayed hypersensitivity to intradermally injected neoarsphenamine. If the animals are treated intravenously with high doses of this compound before sensitization, a specific and permanent immunological tolerance develops. Permanent tolerance is also obtained in previously sensitized animals when an intravenous injection of neoarsphenamine isfollowed 6 hours later by an intradermal one. When, however, the interval between the two injections is extended to 7 or 14 days, no tolerance is observed.

Entities:  

Keywords:  ANTIGEN-ANTIBODY REACTIONS; DERMATITIS, CONTACT; DRUG TOLERANCE; EXPERIMENTAL LAB STUDY; GUINEA PIGS; NEOARSPHENAMINE; TOXICOLOGIC REPORT

Mesh：

Substances：

Year:  1964        PMID： 14149398     DOI： 10.1126/science.144.3620.853

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  Studies on the induction of immunological tolerance by antigen in guinea-pigs already sensitized to dinitrochlorobenzene.

Authors:  J R Frey; A L de Weck; H Geleick
Journal:  Clin Exp Immunol       Date:  1971-01       Impact factor: 4.330

2.  Studies on the induction of immunological unresponsiveness to pneumococcal polysaccharide in mice.

Authors:  G W Siskind; J G Howard
Journal:  J Exp Med       Date:  1966-09-01       Impact factor: 14.307

3.  The X-Y-Z scheme of immunocyte maturation. V. Paralysis of memory cells.

Authors:  V S Byers; E E Sercarz
Journal:  J Exp Med       Date:  1968-10-01       Impact factor: 14.307

4.  INDUCED UNRESPONSIVENESS TO SIMPLE ALLERGENIC CHEMICALS. II. INDEPENDENCE OF DELAYED-TYPE HYPERSENSITIVITY AND FORMATION OF CIRCULATING ANTIBODY.

Authors:  J R BATTISTO; M W CHASE
Journal:  J Exp Med       Date:  1965-04-01       Impact factor: 14.307
  4 in total

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